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Sinonasal Hamartomas: From Nasal Chondromesenchymal Hamartoma to Respiratory Epithelial Adenomatoid Hamartoma. Report of six Cases and Review of the Literature.

作者信息

Li Rongying, Saluja Karan, Lin Mei, Hu Zhihong, Cai Zhenjian, Zhu Hui

机构信息

12340University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.

出版信息

Int J Surg Pathol. 2022 Jun;30(4):448-456. doi: 10.1177/10668969211064211. Epub 2022 Jan 10.


DOI:10.1177/10668969211064211
PMID:35001691
Abstract

Sinonasal hamartomas are uncommon lesions of nasal and sinus cavities. Based on indigenous cellular components and characteristic histologic features, they are further classified into four entities: respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma (SH), chondro-osseous and respiratory epithelial hamartoma (CORE), and nasal chondromesenchymal hamartoma (NCH). REAH, SH, and CORE are seen in adult patients, while NCH predominantly occurs in newborns and infants. Morphologically REAH and SH are composed of respiratory epithelium and seromucinous glands, CORE is related to REAH but with additional feature of chondroid and/or osseous tissue, and NCH is composed of chondroid and stromal elements but devoid of epithelial component. All four lesions can present as sinonasal mass lesions and with associated obstructive symptoms. Given the rarity of these lesions, diagnosis can be challenging, especially in unusual clinical scenario. In this study, we report six cases of sinonasal hamartoma, including one case of NCH, one case of CORE, two cases of SH, and two cases of REAH. All cases were from adult patients including four men and two women. We also review the literature of the clinical and pathologic features of these rare lesions.

摘要

相似文献

[1]
Sinonasal Hamartomas: From Nasal Chondromesenchymal Hamartoma to Respiratory Epithelial Adenomatoid Hamartoma. Report of six Cases and Review of the Literature.

Int J Surg Pathol. 2022-6

[2]
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Hum Pathol. 2019-11-5

[3]
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[4]
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Virchows Arch. 2024-7

[5]
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Histopathology. 2009-1

[6]
Respiratory epithelial adenomatoid hamartomas and chondroosseous respiratory epithelial hamartomas of the sinonasal tract: a case series and literature review.

Am J Rhinol. 2006

[7]
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Pathol Int. 2022-11

[8]
Is Respiratory Epithelial Adenomatoid Hamartoma Related to Central Compartment Atopic Disease?

Am J Rhinol Allergy. 2020-9

[9]
Endoscopic endonasal resection of respiratory epithelial adenomatoid hamartomas of the sinonasal tract.

Int Forum Allergy Rhinol. 2014-12

[10]
Olfactory Epithelial Hamartoma: A New Subtype of Sinonasal Hamartoma.

Am J Surg Pathol. 2018-1

引用本文的文献

[1]
Chondro-Osseous Respiratory Epithelial Adenomatoid Hamartoma of the Skull Base: Report of a Case and Literature Review.

J Neurol Surg Rep. 2025-4-3

[2]
[Clinical characteristics of nasal respiratory epithelial adenomatoid hamartoma].

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023-5

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