Graduate School of Natural and Applied Sciences, Department of Molecular Biology and Genetics, Muğla Sıtkı Koçman University, Muğla, Turkey.
Muğla Vocational School, Chemistry and Chemical Processing Technology Department, Muğla Sıtkı Koçman University, Muğla, Turkey.
Prep Biochem Biotechnol. 2022;52(9):979-989. doi: 10.1080/10826068.2021.2021234. Epub 2022 Jan 9.
The study consists of three parts. In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out. The beads were formed from CoFeO/chitosan and MnFeO/chitosan. TGA and SEM were used for the characterization of core-shell materials. In the second part, swelling experiments of magnetic beads were performed. In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined. Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling. Both prepared systems were found to be suitable for controlled release for 5-Fluorouracil.
本研究由三部分组成。第一部分，基于壳聚糖并包含两种不同磁性纳米粒子的核壳型磁性复合微球的合成与表征。所制备的微球为 CoFeO/壳聚糖和 MnFeO/壳聚糖。通过 TGA 和 SEM 对核壳材料进行了表征。第二部分，进行了磁性微球的溶胀实验。第三部分，在两种不同的磁性材料中以不同的速率包封 5-氟尿嘧啶，在 pH 7.4、pH 6.8 和 pH 1.2 下进行释放实验，并确定了药物释放模型。采用 Korsmeyer-Peppas、Higuchi、一级和零级模型对释放过程进行数学建模。结果表明，两种所制备的体系均适用于 5-氟尿嘧啶的控制释放。
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