基于羧甲基壳聚糖和κ-卡拉胶的磁/pH 响应性微球及其药物控制释放。
Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release.
机构信息
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran.
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran.
出版信息
Carbohydr Polym. 2015 Sep 5;128:112-21. doi: 10.1016/j.carbpol.2015.04.022. Epub 2015 Apr 21.
This paper reports the synthesis of magnetic and pH-sensitive beads derived from κ-carrageenan and carboxymethyl chitosan for drug delivery. The magnetic Fe3O4 nanoparticles were synthesized inside a mixture of biopolymers by in situ method. The structural properties of hydrogel beads were characterized by TEM, SEM, XRD, and VSM techniques. The swelling ratio of beads indicated pH-dependent properties with maximum water absorbing at pH 7.4. Introducing magnetic nanoparticles caused a decrease in swelling capacity from 16.4 to 10 g/g. Drug loading and release efficiency were investigated using diclofenac sodium as a model system. The in vitro drug release studies exhibited significant behaviors on the subject of physiological simulated pHs and external alternative magnetic fields. The maximum cumulative release was around 82% at pH 7.4. The presence of magnetite nanoparticles certainly influenced the drug release patterns. The response of beads to external stimulus makes them as good candidates for novel drug delivery systems.
本文报道了由κ-卡拉胶和羧甲基壳聚糖合成的用于药物输送的磁性和 pH 敏感珠粒。通过原位法在生物聚合物混合物内部合成了磁性 Fe3O4 纳米粒子。通过 TEM、SEM、XRD 和 VSM 技术对水凝胶珠的结构性质进行了表征。珠的溶胀比显示出 pH 依赖性，在 pH 7.4 时最大吸水。引入磁性纳米粒子会导致溶胀能力从 16.4 降低到 10 g/g。使用双氯芬酸钠作为模型系统研究了药物负载和释放效率。体外药物释放研究在生理模拟 pH 值和外部交变磁场方面表现出显著的行为。在 pH 7.4 时，最大累积释放约为 82%。磁铁矿纳米粒子的存在确实影响了药物释放模式。珠对外部刺激的响应使其成为新型药物输送系统的良好候选物。
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