Synthesis and characterization of carboxymethyl chitosan/FeO and MnFeO nanocomposites hydrogels for loading and release of curcumin.

This paper presents the preparation of hydrogel with magnetic properties derived from carboxymethyl chitosan for controlled drug release performance. The magnetic FeO and MnFeO nanoparticles with crosslinked Carboxymethyl Chitosan hydrogel were prepared by using epichlorohydrin as the cross-linker. The structure characterization performed by FT-IR. The XRD analysis was applied for evaluation of crystalline phase of MnFeO and FeO in the hydrogels. The crystallite size of FeO/CMCS and MnFeO/CMCS was calculated to be 30.12, and 44.51 nm, respectively. The presence of MnFeO and FeO in the hydrogels can reason a rough surface morphology which that confirmed by SEM images. The Max. Saturation magnetization value as obtained from hysteresis loop is 105 and 75 Am/kg for FeO/CMCS and MnFeO/CMCS hydrogel, respectively. The FeO and MnFeO on Carboxymethyl Chitosan hydrogels indicated a pH-sensitive for swelling behavior process. The equal amount of FeO and MnFeO on hydrogels have high swelling at pH 6.4. The swelling capacity decreased from 214 to 172% and 144-114% at pH 6.4 with attendance of high amount of MnFeO and FeO on hydrogels compared to other samples, respectively. Drug loading and release performances were investigated by curcumin as a model drug. The maximum curcumin release was obtained 25.1-51.52% at pH = 6.4. The drug releases system demonstrates the high ratio of FeO and MnFeO containing Carboxymethyl Chitosan sample has a great efficiency in curcumin release. The effect of applied magnetic field on drug release for FeO/CMCS was highest compared to MnFeO/CMCS. The results demonstrated that the FeO and MnFeO nanocomposites hydrogel can be applied for novel drug delivery systems.