Science Norms Democracy, UMR 8011 Sorbonne University, Paris, France.
National Scientific and Technical Research Council (CONICET) and Programa de Bioetica, Buenos Aires, Argentina.
J Alzheimers Dis. 2022;86(1):49-52. doi: 10.3233/JAD-215492.
Two potential disease-modifying approaches for dementia are being vigorously tested: the early targeting of the neuropathology of Alzheimer's disease (AD) and multi-domain lifestyle interventions to promote resilience to neuropathology. We apply the "web of information" model of clinical translation to both approaches to argue firstly that tests of treatments aiming to achieve clinically meaningful outcomes should remain simple, and secondly, that building clinically-meaningful treatments should be kept separate from public health policy which means promoting wide-reaching action against risk factors now with available information.
早期靶向阿尔茨海默病（AD）的神经病理学和多领域生活方式干预以促进对神经病理学的适应能力。我们将“信息网络”模型应用于这两种方法，首先认为旨在实现有临床意义的结果的治疗方法的测试应该保持简单，其次，建立有临床意义的治疗方法应该与公共卫生政策分开，这意味着现在就利用现有信息，采取广泛的行动来对抗风险因素。
