“巫毒”的鉴定：埃及一种新出现的滥用物质。
Identification of 'Voodoo': an emerging substance of abuse in Egypt.
作者信息
Hussien Rania, Ahmed Sarah, Awad Hanem, El-Setouhy Maged, El-Shinawi Mohamed, Hirshon Jon Mark
机构信息
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Regulatory Toxicology Lab, Centre of Excellence, National Research Centre, Cairo, Egypt.
出版信息
Int J Environ Anal Chem. 2022;102(1):104-116. doi: 10.1080/03067319.2020.1715384. Epub 2020 Jan 16.
BACKGROUND
'Voodoo' is a new substance of abuse that recently spread among youth in Egypt. It has numerous potentially dangerous effects on humans. However, to date the composition of the main constituents of this compound is unknown.
PURPOSE
We sought to identify the active components of this unknown substance"voodoo".
METHODS
Three samples were collected and analysed by high-performance liquid chromatography with photodiode array detector (HPLC-PAD), gas chromatography/mass spectrometry (GC/MS), and ultra-performance liquid chromatography/mass spectrometry (UPLC-MS/MS) using targeted multiple reaction monitoring (MRM).
RESULTS
HPLC-PAD analysis showed that samples 1 and 2 had some common major peaks, the same retention time, and similar spectra, whereas sample 3 showed different peaks. GC/MS analysis revealed the presence of various putatively identified bioactive compounds, including quinazolines, morphinan alkaloid, cannabinoids, penitrem A, and the well-known synthetic cannabinoid FUB-AMB (methyl(2S)-2-{[1-[(4-fluorophenyl)methyl]indazole-3-carbonyl]amino}-3 methylbutanoate). UPLC-MS/MS analysis revealed the presence of common compounds such as tetrahydrocannabinol (THC), amphetamine, 3,4-methylenedioxyamphetamine, tramadol, and oxazepam.
CONCLUSION
We concluded that Voodoo is a mixture of substances of abuse at varying concentrations.
背景
“巫毒”是一种新型滥用物质，最近在埃及青年中传播。它对人类有许多潜在的危险影响。然而，迄今为止，这种化合物的主要成分组成尚不清楚。
目的
我们试图鉴定这种未知物质“巫毒”的活性成分。
方法
收集了三个样本，并使用靶向多反应监测（MRM）通过带光电二极管阵列检测器的高效液相色谱法（HPLC-PAD）、气相色谱/质谱法（GC/MS）和超高效液相色谱/质谱法（UPLC-MS/MS）进行分析。
结果
HPLC-PAD分析表明，样本1和样本2有一些共同的主要峰、相同的保留时间和相似的光谱，而样本3显示出不同的峰。GC/MS分析揭示了各种推定鉴定出的生物活性化合物的存在，包括喹唑啉、吗啡喃生物碱、大麻素、青霉震颤素A以及著名的合成大麻素FUB-AMB（甲基(2S)-2-{[1-[(4-氟苯基)甲基]吲唑-3-羰基]氨基}-3-甲基丁酸酯）。UPLC-MS/MS分析揭示了常见化合物的存在，如四氢大麻酚（THC）、苯丙胺、3,4-亚甲基二氧基苯丙胺、曲马多和奥沙西泮。
结论
我们得出结论，巫毒是一种不同浓度滥用物质的混合物。
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