Simonian Margaret
University of Californian Los Angeles, David Geffen School of Medicine, Los Angeles, 90095, USA.
Biocell. 2021;45(6):1459-1463. Epub 2021 Sep 1.
Pediatric central nervous system tumors are the most common tumors in children, it constitute 15%-20% of all malignancies in children and are the leading cause of cancer related deaths in children. Proteogenomics is an emerging field of biological research that utilizes a combination of proteomics, genomics, and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic purposes. Integrative proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis.
小儿中枢神经系统肿瘤是儿童最常见的肿瘤，占儿童所有恶性肿瘤的15%-20%，是儿童癌症相关死亡的主要原因。蛋白质基因组学是生物研究中一个新兴领域，它结合了蛋白质组学、基因组学和转录组学，以辅助发现和鉴定用于诊断和治疗目的的生物标志物。对小儿肿瘤进行综合蛋白质基因组学分析，确定了潜在的生物学过程和潜在治疗方法，以及驱动肿瘤发生的体细胞突变和拷贝数变异的功能影响。
