He Changgeng, Zhang Feng, Li Linze, Jiang Changqing, Li Luming
National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China.
Front Neurosci. 2021 Dec 22;15:632822. doi: 10.3389/fnins.2021.632822. eCollection 2021.
Post-implantation localization of deep brain stimulation (DBS) lead based on a magnetic resonance (MR) image is widely used. Existing localization methods use artifact center method or template registration method, which may lead to a considerable deviation of > 2 mm, and result in severe side effects or even surgical failure. Accurate measurement of lead position can instantly inform surgeons of the imprecise implantation. This study aimed to identify the influencing factors in DBS lead post-implantation localization approach, analyze their influence, and describe a localization approach that uses the individual template method to reduce the deviation. We verified that reconstructing direction should be parallel or perpendicular to lead direction, instead of the magnetic field. Besides, we used simplified relationship between magnetic field angle and deviation error to correct the localization results. The mean localization error can be reduced after correction and favors the feasibility of direct localization of DBS lead using MR images. We also discussed influence of noise on localization frequency and the possibility of using only MR images to localize the contacts.
基于磁共振(MR)图像的脑深部电刺激(DBS)电极植入后定位被广泛应用。现有的定位方法采用伪影中心法或模板配准法,这可能导致大于2mm的显著偏差,并导致严重的副作用甚至手术失败。准确测量电极位置可以立即告知外科医生植入不准确的情况。本研究旨在确定DBS电极植入后定位方法中的影响因素,分析其影响,并描述一种使用个体模板法来减少偏差的定位方法。我们验证了重建方向应与电极方向平行或垂直,而不是与磁场方向平行或垂直。此外,我们利用磁场角度与偏差误差之间的简化关系来校正定位结果。校正后平均定位误差可以降低,这有利于使用MR图像直接定位DBS电极的可行性。我们还讨论了噪声对定位频率的影响以及仅使用MR图像定位触点的可能性。