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通过使用石墨烯纤维电极的同时深部脑刺激和 fMRI 进行全激活模式绘图。

Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes.

机构信息

Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.

Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.

出版信息

Nat Commun. 2020 Apr 14;11(1):1788. doi: 10.1038/s41467-020-15570-9.

DOI:10.1038/s41467-020-15570-9
PMID:32286290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7156737/
Abstract

Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging (fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring neuromodulatory mechanisms of DBS therapies. Previous DBS-fMRI studies could not provide full activation pattern maps due to poor MRI compatibility of the DBS electrodes, which caused obstruction of large brain areas on MRI scans. Here, we fabricate graphene fiber (GF) electrodes with high charge-injection-capacity and little-to-no MRI artifact at 9.4T. DBS-fMRI with GF electrodes at the subthalamic nucleus (STN) in Parkinsonian rats reveal robust blood-oxygenation-level-dependent responses along the basal ganglia-thalamocortical network in a frequency-dependent manner, with responses from some regions not previously detectable. This full map indicates that STN-DBS modulates both motor and non-motor pathways, possibly through orthodromic and antidromic signal propagation. With the capability for full, unbiased activation pattern mapping, DBS-fMRI using GF electrodes can provide important insights into DBS therapeutic mechanisms in various neurological disorders.

摘要

同时进行深部脑刺激 (DBS) 和功能磁共振成像 (fMRI) 构成了一种强大的工具，可以阐明大脑功能连接，并探索 DBS 治疗的神经调节机制。以前的 DBS-fMRI 研究由于 DBS 电极对 MRI 的兼容性差，无法提供完整的激活模式图，这导致 MRI 扫描中大脑大片区域受阻。在这里，我们制造了具有高注入容量和几乎没有 MRI 伪影的石墨烯纤维 (GF) 电极，在 9.4T 下。帕金森病大鼠的丘脑底核 (STN) 进行的 DBS-fMRI 研究显示，在基底神经节-丘脑皮质网络中，以频率依赖的方式产生了强烈的血氧水平依赖性反应，一些以前无法检测到的区域也产生了反应。这种完整的图谱表明，STN-DBS 调节运动和非运动通路，可能通过顺行和逆行信号传递。使用 GF 电极进行的 DBS-fMRI 具有完整、无偏的激活模式映射能力，可以为各种神经疾病的 DBS 治疗机制提供重要的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/71ed5c0f89ae/41467_2020_15570_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/88627dfafbf8/41467_2020_15570_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/f2ba744afca1/41467_2020_15570_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/3d3402204def/41467_2020_15570_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/e5dde0a512b9/41467_2020_15570_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/31a716decb47/41467_2020_15570_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/71ed5c0f89ae/41467_2020_15570_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/88627dfafbf8/41467_2020_15570_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/f2ba744afca1/41467_2020_15570_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/3d3402204def/41467_2020_15570_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/e5dde0a512b9/41467_2020_15570_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/31a716decb47/41467_2020_15570_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d10/7156737/71ed5c0f89ae/41467_2020_15570_Fig6_HTML.jpg

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