Feng Xiangjun, Niu Lili, Long Meng, Luo Kaixuan, Huang Xiaowei, Chen Moxian, Lin Zhengrong, Zhou Wei, Yi Shasha, Ao Lijuan
The School of Rehabilitation, Kunming Medical University, 1168 West Chunrong Road, Chenggong, Kunming 650500, China.
General Surgery Department of Geriatrics, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, China.
Evid Based Complement Alternat Med. 2021 Dec 31;2021:6510383. doi: 10.1155/2021/6510383. eCollection 2021.
Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of the anterior cingulate cortex (ACC) effectively improved chronic pain in the chronic compress injury mice model at different stages of neuropathic pain. The mechanical threshold of pain was recorded in the nociceptive tests. We found FUS stimulation elevated the mechanical threshold of pain in both short-term ( < 0.01) and long-term ( < 0.05) experiments. Furthermore, we determined protein expression differences in ACC between the control group, the intervention group, and the Sham group to analyze the underlying mechanism of FUS stimulation in improving neuropathic pain. Additionally, the results showed FUS stimulation led to alterations in differential proteins in long-term experiments, including cellular processes, cellular signaling, and information storage and processing. Our findings indicate FUS may effectively alleviate mechanical neuropathic pain via the ACC's stimulation, especially in the chronic state.
聚焦超声（FUS）是一种通过调节中枢神经系统来治疗慢性疼痛的潜在工具。在此，我们旨在确定经颅聚焦超声刺激前扣带回皮质（ACC）是否能有效改善慢性压迫损伤小鼠模型在神经性疼痛不同阶段的慢性疼痛。在伤害性测试中记录疼痛的机械阈值。我们发现，在短期（<0.01）和长期（<0.05）实验中，聚焦超声刺激均提高了疼痛的机械阈值。此外，我们测定了对照组、干预组和假手术组之间前扣带回皮质的蛋白质表达差异，以分析聚焦超声刺激改善神经性疼痛的潜在机制。此外，结果表明，在长期实验中，聚焦超声刺激导致差异蛋白质发生变化，包括细胞过程、细胞信号传导以及信息存储和处理。我们的研究结果表明，聚焦超声可能通过刺激前扣带回皮质有效缓解机械性神经性疼痛，尤其是在慢性状态下。
