癌症引发骨痛的神经生理学机制。
Neurophysiological mechanisms of cancer-induced bone pain.
机构信息
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang, 325027, China.
Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
出版信息
J Adv Res. 2021 Jun 11;35:117-127. doi: 10.1016/j.jare.2021.06.006. eCollection 2022 Jan.
BACKGROUND
Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected.
AIM OF REVIEW
Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies.
KEY SCIENTIFIC CONCEPTS OF REVIEW
Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.
背景
癌症相关性骨痛（CIBP）是影响癌症幸存者生活质量的重要因素。此外，目前的临床实践和科学研究表明，神经病理性疼痛是 CIBP 的代表性组成部分。然而，鉴于癌症病情的多变性和神经病理性疼痛的复杂性，相关机制不断得到补充，但尚未完善。
综述目的
因此，本综述重点介绍该领域基础研究的最新进展，并提出潜在的治疗靶点、代表性药物和即将出现的治疗方法。
综述的关键科学概念
值得注意的是，中枢敏化、神经炎症、神经胶质细胞激活和酸性环境等因素被认为与 CIBP 中的神经病理性疼痛有关。然而，为了开发高效药物，仍需要进一步研究以确定 CIBP 的机制。此外，需要更多关注晚期癌症患者的护理。
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