Garcia Tiago Severo, Engelholm Jean-Luc, Vouche Michaël, Leitão Cristiane Bauermann
Department of Radiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Department of Radiology, Institute Jules Bordet, Brussels, Belgium.
J Clin Imaging Sci. 2021 Sep 27;11:50. doi: 10.25259/JCIS_72_2021. eCollection 2021.
The objectives of the study was to compare pancreatic perfusion by computed tomography in type 2 diabetes and non-diabetic subjects.
In this case-control study, 17 patients with type 2 diabetes and 22 non-diabetic controls were examined with a dynamic 192-slices perfusion computed tomography for estimating pancreatic perfusion parameters.
Thirty-nine patients were included (22 with Type 2 diabetes mellitus [T2DM]), with a mean age of 64 years. There were significant differences in some pancreatic perfusion parameters in patients with and without type 2 diabetes. Blood volume (BV) was lower in pancreatic head (with T2DM: 14.0 ± 3.4 vs. without T2DM: 16.1 ± 2.4 mL/100 mL; = 0.033), pancreatic tail (with: 14.4 ± 3.6 vs. without: 16.8 ± 2.5 mL/100 mL; = 0.023), and in whole pancreas (with: 14.2 ± 3.2 vs. without: 16.2 ± 2.5 mL/100 mL; = 0.042). Similar behavior was observed with mean transit time (MTT) in pancreatic head (with: 7.0 ± 1.0 vs. without: 7.9 ± 1.2 s; = 0.018), pancreatic tail (with: 6.6 ± 1.3 vs. without: 7.7 ± 0.9 s; = 0.005), and in whole pancreas (with: 6.8 ± 1.0 vs. without: 7.7 ± 0.9 s; = 0.016). BV in head, tail, and whole pancreas had negative correlations with age (head r: -0.352, = 0.032; tail r: -0.421, = 0.031; whole pancreas r: -0.439, = 0.007), and fasting plasma glucose (head r: -0.360, = 0.031; tail r: -0.483, = 0.003; whole pancreas r: -0.447, = 0.006). In a multivariate linear regression model, HbA1c was independently associated with decrease in BV in whole pancreas (β: -0.884; CI95%: -1.750 to -0.017; = 0.046).
Pancreatic BV and MTT were significantly lower in patients with type 2 diabetes. BV was decreased with older age and poorer glycemic control.
本研究的目的是通过计算机断层扫描比较2型糖尿病患者和非糖尿病患者的胰腺灌注情况。
在这项病例对照研究中，对17例2型糖尿病患者和22例非糖尿病对照者进行了动态192层灌注计算机断层扫描，以评估胰腺灌注参数。
共纳入39例患者（22例2型糖尿病[T2DM]患者），平均年龄64岁。2型糖尿病患者和非糖尿病患者的一些胰腺灌注参数存在显著差异。胰头的血容量（BV）较低（2型糖尿病患者：14.0±3.4 vs. 非2型糖尿病患者：16.1±2.4 mL/100 mL；P = 0.033），胰尾（2型糖尿病患者：14.4±3.6 vs. 非2型糖尿病患者：16.8±2.5 mL/100 mL；P = 0.023），以及整个胰腺（2型糖尿病患者：14.2±3.2 vs. 非2型糖尿病患者：16.2±2.5 mL/100 mL；P = 0.042）。胰头、胰尾和整个胰腺的平均通过时间（MTT）也有类似表现（胰头：2型糖尿病患者：7.0±1.0 vs. 非2型糖尿病患者：7.9±1.2秒；P = 0.018，胰尾：2型糖尿病患者：6.6±1.3 vs. 非2型糖尿病患者：7.7±0.9秒；P = 0.005，整个胰腺：2型糖尿病患者：6.8±1.0 vs. 非2型糖尿病患者：7.7±0.9秒；P = 0.016）。胰头、胰尾和整个胰腺的BV与年龄呈负相关（胰头r：-0.352，P = 0.032；胰尾r：-0.421，P = 0.031；整个胰腺r：-0.439，P = 0.007），与空腹血糖也呈负相关（胰头r：-0.360，P = 0.031；胰尾r：-0.483，P = 0.003；整个胰腺r：-0.447，P = 0.006）。在多变量线性回归模型中，糖化血红蛋白（HbA1c）与整个胰腺BV的降低独立相关（β：-0.884；95%CI：-1.750至-0.017；P = 0.046）。
2型糖尿病患者的胰腺BV和MTT显著降低。BV随着年龄增长和血糖控制不佳而降低。
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