确定用于人体手部经皮骨质量评估的最佳拉曼光谱空间偏移量。
Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands.
作者信息
Chen Keren, Massie Christine, Awad Hani A, Berger Andrew J
机构信息
The Institute of Optics, University of Rochester, Rochester, NY 14620, USA.
Joint co-authors.
出版信息
Biomed Opt Express. 2021 Nov 11;12(12):7517-7525. doi: 10.1364/BOE.440297. eCollection 2021 Dec 1.
Abstract
Spatially offset Raman spectroscopy (SORS) is able to detect bone signal transcutaneously and could assist in predicting bone fracture risk. Criteria for optimal source-detector offsets for transcutaneous human measurements, however, are not well-established. Although larger offsets yield a higher percentage of bone signal, the absolute amount of bone signal decreases. Spectral unmixing into bone, adipose, and non-adipose components was employed to quantify changes in bone signal to noise ratio across a range of offsets, and optimal offsets for phalanx and metacarpal measurements were determined. The bone signal to noise ratio was maximized at offsets ranging from 4-6 mm.
摘要
空间偏移拉曼光谱（SORS）能够经皮检测骨骼信号，并有助于预测骨折风险。然而，用于经皮人体测量的最佳源探测器偏移标准尚未完全确立。尽管较大的偏移会产生更高比例的骨骼信号，但骨骼信号的绝对量会减少。采用光谱解混为骨骼、脂肪和非脂肪成分的方法，以量化一系列偏移范围内骨骼信噪比的变化，并确定了指骨和掌骨测量的最佳偏移。在4-6毫米的偏移范围内，骨骼信噪比达到最大值。
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