Habadi Mohammed I, Hamza Nashaat, Balla Abdalla Tarig H, Al-Gedeei Afnan
Family Medicine, University of Jeddah, Jeddah, SAU.
Infectious Disease, International Medical Center, Jeddah, SAU.
Cureus. 2021 Dec 4;13(12):e20158. doi: 10.7759/cureus.20158. eCollection 2021 Dec.
The possibilities of coronavirus disease 2019 (COVID-19) to present with atypical manifestations have reported. Information of COVID-19 atypical signs and symptoms is still emerging globally. One of these presentations is persistent hiccups. One of the hypotheses is that COVID-19 has been linked to several neurological manifestations and effects. Some observations noticed phrenic nerve paralysis after COVID-19 infection leading to pulmonary failure. We report one case of COVID-19-positive patient where he presented with persistent hiccups. Many predisposing factors might lead to the development of hiccups in COVID-19 infection such as a history of smoking, phrenic and vagus nerve damage or irritation, high inflammatory markers, lower lobe pneumonia, ground-glass-like appearance on x-rays. We hypothesize that hiccups are the first sign of serious deterioration of patients with COVID-19 and such patients are at high risk of developing kidney injury and intubation.
2019冠状病毒病（COVID-19）出现非典型表现的可能性已有报道。COVID-19非典型体征和症状的信息仍在全球不断涌现。其中一种表现是持续性呃逆。一种假设是，COVID-19与多种神经表现和影响有关。一些观察发现，COVID-19感染后膈神经麻痹导致呼吸衰竭。我们报告1例COVID-19阳性患者，该患者出现持续性呃逆。许多诱发因素可能导致COVID-19感染时呃逆的发生，如吸烟史、膈神经和迷走神经损伤或刺激、炎症指标高、下叶肺炎、X线表现为磨玻璃样外观。我们推测，呃逆是COVID-19患者病情严重恶化的首个迹象，此类患者发生肾损伤和插管的风险很高。
