Alavudeen Sirajudeen S, Asiri Anas Ali, Fageeh Shatha Abdulrahman, Aljarie Ahmed Abdoh, Iqbal Mir Javid, Khan Noohu Abdulla, Tabassum Fauzia, Rahamathulla Mohamed, Hani Umme, Akhtar Md Sayeed
Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Department of Paediatrics, Pediatric Infectious Diseases, Abha Maternity and Children Hospital, Abha, Saudi Arabia.
Front Pediatr. 2021 Dec 23;9:740106. doi: 10.3389/fped.2021.740106. eCollection 2021.
Complications of urinary tract infections (UTIs) like kidney failure and septicaemia develop once infections spread from the upper urinary tract to other parts of the body by haematogenous dissemination and they pose great health and economic burden to the countries. This retrospective study was conducted among 132 patients with bacterial UTIs in the inpatient department of tertiary care hospital in Abha, Saudi Arabia. During the study period, () and () along with other 15 different bacteria were isolated. A significant difference ( < 0.05) was observed between the male and female children population in different age groups. We observed fever (84.09%) as a major symptom ( < 0.05), and seizure (9%) was reported as a major concomitant condition among UTI cases. Around 31.82% of was found to be the most common uropathogens in pediatric cases followed by 25% in . was observed to be more susceptible (92.86%) to amikacin, ceftriaxone, levofloxacin, ertapenem, gentamycin, meropenem, piperacillin-tazobactam, tigecycline, and ceftazidime. However, meropenem, tigecycline, and amikacin were observed to be effective in 100% of cases of . Meanwhile, cephalosporins were the most commonly prescribed drug category among different classes of drugs. Almost 99% of pediatric cases, based on their age, were admitted to the ward, and drugs were administered intravenously. We concluded that microbiology laboratory evidence on the causative organisms and choice of treatment together allows tailoring appropriate treatment regimens in conjunction with clinical experiences.
一旦尿路感染(UTIs)通过血行播散从泌尿系统上行感染扩散至身体其他部位,就会引发诸如肾衰竭和败血症等并发症,给各国带来巨大的健康和经济负担。本回顾性研究在沙特阿拉伯阿卜哈市一家三级护理医院的住院部对132例细菌性尿路感染患者进行。在研究期间,分离出了()和()以及其他15种不同的细菌。不同年龄组的男童和女童人群之间观察到显著差异(P<0.05)。我们观察到发热(84.09%)是主要症状(P<0.05),并且癫痫发作(9%)被报告为尿路感染病例中的主要伴随病症。在儿科病例中,约31.82%的(细菌名称未给出)被发现是最常见的尿路病原体,其次是(另一细菌名称未给出)占25%。观察到(细菌名称未给出)对阿米卡星、头孢曲松、左氧氟沙星、厄他培南、庆大霉素、美罗培南、哌拉西林 - 他唑巴坦、替加环素和头孢他啶更敏感(92.86%)。然而,美罗培南、替加环素和阿米卡星在100%的(另一细菌名称未给出)病例中被观察到有效。同时,头孢菌素是不同药物类别中最常用的处方药物类别。几乎99%的儿科病例根据其年龄被收治入院,药物通过静脉给药。我们得出结论,关于致病生物的微生物学实验室证据和治疗选择共同结合临床经验能够制定合适的治疗方案。