Rizwan Mohd, Akhtar Mohd, Najmi Abul Kalam, Singh Kuldeep
Department of Pharmacology, School of Pharmaceutical Education and Research (Formerly: Faculty of Pharmacy), Jamia Hamdard (Hamdard University), New Delhi, India.
Hakim Abdul Hameed Centenary Hospital, HIMSR (Jamia Hamdard), Hamdard Nagar, New Delhi, India.
Drug Res (Stuttg). 2018 Jul;68(7):415-420. doi: 10.1055/a-0576-0079. Epub 2018 Mar 12.
This study was carried out to record the sensitivity/resistance pattern of and towards antimicrobial drugs prescribed to urinary tract infection (UTI) patients.
A total of 68 bacteriologically proven simple UTI patients were included in the study, based on inclusion and exclusion criteria. Subjects demographics, antibiotics prescribed, sensitivity pattern of antibiotics towards the urinary pathogens were recorded in drug utilization and documentation form.
The mean age of the patients was 29.32 years. The maximum number of patients fell under the age group 21-30 years. The maximum no of male and female patients belonged to the age group 21-30 years, 82.35% were females and 17.64% were males. found to be the most common uropathogens followed by Nitrofurantoin was the most commonly prescribed drug followed by ciprofloxacin, levofloxacin and amoxicillin + clavulanic acid and amikacin. isolates showed high resistance for ampicillin followed by cotrimoxazole, norfloxacin, ciprofloxacin, gentamicin, tetracycline and ceftazidime and least resistance to amikacin, nitrofurantoin. isolates were highly resistant against ceftazidime, ampicilline, cotrimoxazole, nitrofurantoin, gentamicin, amoxicillin + sulbactam. Overall, the antibiotic against with high resistance found was ampicillin followed by cotrimoxazole, gentamicin, ceftazidime, norfloxacin, ciprofloxacin, tetracycline, levofloxacin, cefepime and least resistance to amikacin, netilmicin and nitrofurantoin.
Majority of UTIs in this study were caused by followed by The high resistance was found with ampicillin (75%). Nitrofurantoin was the most commonly prescribed drug followed by other flouroquinolones.
本研究旨在记录[具体细菌名称1]和[具体细菌名称2]对尿路感染（UTI）患者所开抗菌药物的敏感/耐药模式。
根据纳入和排除标准，共有68例经细菌学证实的单纯性UTI患者纳入本研究。在药物使用和记录表格中记录受试者的人口统计学信息、所开抗生素、抗生素对尿路病原体的敏感模式。
患者的平均年龄为29.32岁。最大数量的患者属于21 - 30岁年龄组。男性和女性患者数量最多的年龄组均为21 - 30岁，女性占82.35%，男性占17.64%。[具体细菌名称1]被发现是最常见的尿路病原体，其次是[具体细菌名称2]。呋喃妥因是最常开具的药物，其次是环丙沙星、左氧氟沙星、阿莫西林 + 克拉维酸和阿米卡星。[具体细菌名称1]分离株对氨苄西林表现出高耐药性，其次是复方新诺明、诺氟沙星、环丙沙星、庆大霉素、四环素和头孢他啶，对阿米卡星、呋喃妥因耐药性最低。[具体细菌名称2]分离株对头孢他啶、氨苄西林、复方新诺明、呋喃妥因、庆大霉素、阿莫西林 + 舒巴坦高度耐药。总体而言，发现耐药性高的抗生素是氨苄西林，其次是复方新诺明、庆大霉素、头孢他啶、诺氟沙星、环丙沙星、四环素、左氧氟沙星、头孢吡肟，对阿米卡星、奈替米星和呋喃妥因耐药性最低。
本研究中大多数UTI由[具体细菌名称1]引起，其次是[具体细菌名称2]。发现氨苄西林耐药性高（75%）。呋喃妥因是最常开具的药物，其次是其他氟喹诺酮类药物。
