基于亲水性四苯乙烯的四阳离子环番：NADPH识别及荧光开关细胞成像
Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch.
作者信息
Wu Dan, Zhang Zhankui, Yu Xinyang, Bai Bing, Qi Shaolong
机构信息
College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, China.
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.
出版信息
Front Chem. 2021 Dec 22;9:817720. doi: 10.3389/fchem.2021.817720. eCollection 2021.
A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc could light up tumor cells, acting as a GSH-responsive fluorescent switch to image cells with high resolution.
合成了一种基于亲水性热塑性弹性体的四阳离子环番TPE-cyc，它可以捕获细胞内的烟酰胺腺嘌呤二核苷酸磷酸，并增强肿瘤细胞清除活性氧（ROS）的抗氧化能力。同时，在细胞内谷胱甘肽（GSH）的还原作用下，TPE-cyc可以使肿瘤细胞发光，作为一种GSH响应型荧光开关，以高分辨率对细胞进行成像。
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