Larsson P, Holmdahl R
Department of Medical and Physiological Chemistry, Uppsala University, Sweden.
Scand J Immunol. 1987 Nov;26(5):579-83. doi: 10.1111/j.1365-3083.1987.tb02292.x.
Immunization of female Lewis rats with bovine type II collagen induces a severe polyarthritis with an incomplete penetration. Castration of the rats increased the incidence to 94% compared with 50% among sham-operated controls. When castrated female rats were implanted with silicone capsules containing beta-oestradiol they developed arthritis with a delayed onset and a decreased severity compared with castrated rats implanted with empty Silastic capsules. The levels of anti-type II collagen auto-antibodies were not affected by castration or oestrogen treatment. These findings show that oestrogen suppresses the development of collagen arthritis in rats and that this effect is mediated by mechanisms other than anti-type II collagen auto-antibodies.
用牛II型胶原免疫雌性Lewis大鼠会诱发严重的多关节炎，且关节穿透不完全。与假手术对照组中50%的发病率相比，大鼠去势后发病率增加到94%。当给去势的雌性大鼠植入含有β-雌二醇的硅胶胶囊时，与植入空硅胶胶囊的去势大鼠相比，它们患关节炎的发病延迟且严重程度降低。抗II型胶原自身抗体的水平不受去势或雌激素治疗的影响。这些发现表明，雌激素抑制大鼠胶原性关节炎的发展，且这种作用是由抗II型胶原自身抗体以外的机制介导的。
