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环孢素对II型胶原诱导的大鼠关节炎的抗关节炎和免疫抑制作用。

The anti-arthritic and immunosuppressive effects of cyclosporine on arthritis induced in the rat by type II collagen.

作者信息

Henderson B, Staines N A, Burrai I, Cox J H

出版信息

Clin Exp Immunol. 1984 Jul;57(1):51-6.

PMID:6744674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536083/
Abstract

The influence of cyclosporine (CsA) on the induction and pathogenesis of type II collagen-induced arthritis has been investigated in inbred and outbred Wistar rats. The proportion of animals developing disease and the severity of disease they developed were both diminished by treatment with CsA. These effects were accompanied by a marked suppression of the antibody response to both the immunizing collagen and also to rat type II collagen. CsA treatment also resulted in a decreased accumulation of lymphocytes in arthritic joints. The results indicate that the anti-arthritic and immunosuppressive effects of CsA probably result from a modification of both systemic antibody-mediated and local cell-mediated immunity.

摘要

在近交系和远交系Wistar大鼠中，研究了环孢素（CsA）对II型胶原诱导性关节炎的诱导和发病机制的影响。用CsA治疗可降低发病动物的比例及其所患疾病的严重程度。这些作用伴随着对免疫原性胶原以及大鼠II型胶原抗体反应的显著抑制。CsA治疗还导致关节炎关节中淋巴细胞的积聚减少。结果表明，CsA的抗关节炎和免疫抑制作用可能源于全身抗体介导免疫和局部细胞介导免疫的改变。

相似文献

1
The anti-arthritic and immunosuppressive effects of cyclosporine on arthritis induced in the rat by type II collagen.环孢素对II型胶原诱导的大鼠关节炎的抗关节炎和免疫抑制作用。
Clin Exp Immunol. 1984 Jul;57(1):51-6.
2
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引用本文的文献

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2
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Drugs. 1993 Jun;45(6):953-1040. doi: 10.2165/00003495-199345060-00007.
4
Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats.给大鼠胃内施用II型胶原蛋白可延缓胶原诱导性关节炎的发病和严重程度。
Clin Exp Immunol. 1986 Jun;64(3):581-6.
5
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Ann Rheum Dis. 1986 Apr;45(4):339-44. doi: 10.1136/ard.45.4.339.
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本文引用的文献

1
Autoimmunity to collagen in adjuvant arthritis of rats.大鼠佐剂性关节炎中对胶原蛋白的自身免疫反应。
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Collagen-induced arthritis in the rat: modification of immune and arthritic responses by free collagen and immune anti-collagen antiserum.大鼠胶原诱导性关节炎：游离胶原和免疫抗胶原抗血清对免疫和关节炎反应的影响
Immunology. 1981 Dec;44(4):737-44.
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Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis.大鼠Ⅱ型胶原诱导性关节炎。血清被动转移及IgG抗胶原抗体可引发关节炎的证据。
J Exp Med. 1982 Jan 1;155(1):1-16. doi: 10.1084/jem.155.1.1.
5
Native type II collagen-induced arthritis in the rat. II. Relationship between the humoral immune response to native type II collagen and arthritis.大鼠天然II型胶原诱导性关节炎。II. 对天然II型胶原的体液免疫反应与关节炎之间的关系。
J Rheumatol. 1980 Nov-Dec;7(6):775-82.
6
Serum transfer of collagen-induced arthritis in mice.小鼠胶原诱导性关节炎的血清转移
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7
Effect of cyclosporine on experimental autoimmune thyroiditis in mice.环孢素对小鼠实验性自身免疫性甲状腺炎的影响。
Transplantation. 1983 May;35(5):518-20.
8
Attenuation of an adjuvant arthritis by type II collagen.
J Immunol. 1983 Jun;130(6):2689-92.
9
Lines of T lymphocytes induce or vaccinate against autoimmune arthritis.T淋巴细胞系可诱导针对自身免疫性关节炎的免疫反应或进行疫苗接种。
Science. 1983 Jan 7;219(4580):56-8. doi: 10.1126/science.6336851.
10
Role of T lymphocytes in collagen II induced arthritis in rats.T淋巴细胞在大鼠Ⅱ型胶原诱导性关节炎中的作用
Clin Exp Immunol. 1983 Jan;51(1):117-25.