帕金森病中强迫性仪式动作和成瘾行为的神经精神特征
Neuropsychiatric Features of Punding and Hobbyism in Parkinson's Disease.
作者信息
Barbosa Pedro, O'Sullivan Sean S, Joyce Eileen, Lees Andrew J, Warner Thomas T, Djamshidian Atbin
机构信息
Reta Lila Weston Institute of Neurological Studies, Department of Clinical Movement Disorder and Neuroscience Institute of Neurology, University College London London United Kingdom.
The National Hospital for Neurology and Neurosurgery London United Kingdom.
出版信息
Mov Disord Clin Pract. 2021 Nov 11;9(1):82-86. doi: 10.1002/mdc3.13363. eCollection 2022 Jan.
BACKGROUND
Little is known about the cognitive and neuropsychiatric profile associated with punding and hobbyism in Parkinson's disease (PD).
OBJECTIVE
To compare the clinical and neuropsychological features of PD patients with punding and hobbyism to PD controls.
METHODS
The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) was used as a screening tool, and a structured interview was used to diagnose punding/hobbyism. Clinical and neuropsychological assessment was conducted with validated questionnaires/scales.
RESULTS
Twenty-one patients with PD and punding (PD + pu) were compared to 26 with hobbyism (PD + h) and 25 PD controls. PD + pu patients showed higher levels of anxiety, non-motor symptoms and motor symptoms, and lower Frontal Assessment Battery scores. The PD + h group exhibited similar levels of anxiety and motor fluctuations to the PD + pu group.
CONCLUSION
PD + pu showed increased anxiety and frontal lobe dysfunction, similar to PD + h. Hobbyism could be a prodromal phase with increased risk of leading to punding.
背景
关于帕金森病（PD）中与强迫性仪式动作和过度爱好相关的认知及神经精神特征，人们了解甚少。
目的
比较患有强迫性仪式动作和过度爱好的PD患者与PD对照者的临床和神经心理学特征。
方法
使用帕金森病冲动控制障碍问卷-评定量表（QUIP-RS）作为筛查工具，并采用结构化访谈来诊断强迫性仪式动作/过度爱好。使用经过验证的问卷/量表进行临床和神经心理学评估。
结果
将21例患有强迫性仪式动作的PD患者（PD+pu）与26例有过度爱好的患者（PD+h）以及25例PD对照者进行比较。PD+pu患者表现出更高水平的焦虑、非运动症状和运动症状，且额叶评估量表得分更低。PD+h组的焦虑水平和运动波动与PD+pu组相似。
结论
PD+pu表现出焦虑增加和额叶功能障碍，与PD+h相似。过度爱好可能是一个前驱阶段，导致强迫性仪式动作的风险增加。
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