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尿液药物检测:当前的建议和最佳实践。

Urine drug testing: current recommendations and best practices.

机构信息

Texas Pain Rehabilitation Institute, Houston, TX, USA.

出版信息

Pain Physician. 2012 Jul;15(3 Suppl):ES119-33.

Abstract

BACKGROUND

The precise role of urine drug testing (UDT) in the practice of pain medicine is currently being defined. Confusion exists as to best practices, and even to what constitutes standard of care. A member survey by our state pain society revealed variability in practice and a lack of consensus.

OBJECTIVE

The authors sought to further clarify the importance of routine UDT as an important part of an overall treatment plan that includes chronic opioid prescribing. Further, we wish to clarify best practices based on consensus and data where available.

METHODS

A 20-item membership survey was sent to Texas Pain Society members. A group of chronic pain experts from the Texas Pain Society undertook an effort to review the best practices in the literature. The rationale for current UDT practices is clarified, with risk management strategies outlined, and recommendations for UDT outlined in detail. A detailed insight into the limitations of point-of-care (enzyme-linked immunosorbent assay, test cups, test strips) versus the more sensitive and specific laboratory methods is provided.

LIMITATIONS

Our membership survey was of a limited sample size in one geographic area in the United States and may not represent national patterns. Finally, there is limited data as to the efficacy of UDT practices in improving compliance and curtailing overall medication misuse.

CONCLUSIONS

UDT must be done routinely as part of an overall best practice program in order to prescribe chronic opioid therapy. This program may include risk stratification; baseline and periodic UDT; behavioral monitoring; and prescription monitoring programs as the best available tools to monitor chronic opioid compliance.

摘要

背景

尿液药物检测(UDT)在疼痛医学实践中的精确作用目前正在确定。最佳实践存在混淆,甚至什么是标准护理也存在混淆。我们州疼痛学会的一项成员调查显示,实践存在差异,而且缺乏共识。

目的

作者试图进一步澄清常规 UDT 的重要性,UDT 是包括慢性阿片类药物处方在内的整体治疗计划的重要组成部分。此外,我们希望根据共识和现有数据来澄清最佳实践。

方法

向德克萨斯州疼痛学会的成员发送了一份 20 项的成员调查。德克萨斯州疼痛学会的一组慢性疼痛专家努力审查文献中的最佳实践。阐明了当前 UDT 实践的基本原理,概述了风险管理策略,并详细概述了 UDT 的建议。详细了解即时检测(酶联免疫吸附试验、测试杯、测试条)与更敏感和特异性实验室方法的局限性。

局限性

我们的会员调查样本数量有限,仅在美国一个地理区域进行,可能无法代表全国模式。最后,关于 UDT 实践在提高依从性和减少整体药物滥用方面的疗效的数据有限。

结论

UDT 必须作为慢性阿片类药物治疗的整体最佳实践计划的一部分进行常规检测。该计划可能包括风险分层;基线和定期 UDT;行为监测;和处方监测计划,作为监测慢性阿片类药物依从性的最佳可用工具。

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