该定位基因座由一个功能获得性突变编码。
The mapping locus is encoded by a gain-of-function mutation in .
作者信息
Rich Matthew S, Nix Paola, Jorgensen Erik M
机构信息
School of Biological Sciences, Howard Hughes Medical Institute, University of Utah, USA.
出版信息
MicroPubl Biol. 2022 Jan 5;2022. doi: 10.17912/micropub.biology.000506. eCollection 2022.
Abstract
We mapped to the locus (encoded by the gene W01F3.3) on the far-right end of chromosome V. The canonical allele of , , is an in-frame deletion in a conserved exon of the protein that creates a gain-of-function roller phenotype. deletes a short peptide of unknown function conserved in nematodes.
摘要
我们将其定位到五号染色体最右端的基因座（由W01F3.3基因编码）。的标准等位基因，即，是该蛋白质保守外显子中的一个框内缺失，产生了功能获得性的滚动表型。删除了线虫中保守的一段功能未知的短肽。
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