圆锥角膜患者的结膜印迹细胞学和泪液功能
Conjunctival Impression Cytology and Tear Function in Patients with Keratoconus.
作者信息
Ozcan Deniz Ozarslan, Ozcan Sait Coskun, Gursoy Didar
机构信息
Department of Ophthalmology, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
Department of Pathology, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
出版信息
Beyoglu Eye J. 2021 Jun 8;6(2):79-83. doi: 10.14744/bej.2021.83584. eCollection 2021.
OBJECTIVES
The aim of this study was to evaluate the ocular surface alterations of conjunctival cytological changes and tear function in patients with keratoconus.
METHODS
A total of 98 eyes with keratoconus and 68 eyes of age- and sex- matched healthy subjects were included in this prospective study. Ophthalmological evaluations, including Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), ocular surface staining (OSS), Schirmer test, and conjunctival impression cytology (CIC), were performed.
RESULTS
The mean participant age was 23.4±5.3 years in the keratoconus group and 24.9±6.0 years in the control group. In the keratoconus group, the mean OSDI and OSS scores were statistically significantly higher than those of the controls, and the Schirmer and TBUT results were statistically significantly lower (all p<0.001). The severity of keratoconus was positively correlated with the CIC grade (r=0.292; p=0.004).
CONCLUSION
Keratoconus results in deterioration of the ocular surface, including CIC and tear function parameters. The grade of keratoconus appears to be associated with conjunctival cytologic changes.
目的
本研究旨在评估圆锥角膜患者结膜细胞学变化和泪液功能的眼表改变。
方法
本前瞻性研究纳入了98只圆锥角膜患眼和68只年龄及性别匹配的健康受试者眼睛。进行了眼科评估，包括眼表疾病指数（OSDI）、泪膜破裂时间（TBUT）、眼表染色（OSS）、泪液分泌试验和结膜印迹细胞学检查（CIC）。
结果
圆锥角膜组受试者的平均年龄为23.4±5.3岁，对照组为24.9±6.0岁。圆锥角膜组的平均OSDI和OSS评分在统计学上显著高于对照组，泪液分泌试验和TBUT结果在统计学上显著低于对照组（均p<0.001）。圆锥角膜的严重程度与CIC分级呈正相关（r=0.292；p=0.004）。
结论
圆锥角膜导致眼表恶化，包括CIC和泪液功能参数。圆锥角膜的分级似乎与结膜细胞学变化有关。
Zotero 插件