Bestea Louise, Paoli Marco, Arrufat Patrick, Ronsin Brice, Carcaud Julie, Sandoz Jean-Christophe, Velarde Rodrigo, Giurfa Martin, de Brito Sanchez Maria Gabriela
Research Centre on Animal Cognition, Centre for Integrative Biology, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France.
Centre for Integrative Biology, Université de Toulouse, CNRS, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France.
iScience. 2021 Dec 11;25(1):103619. doi: 10.1016/j.isci.2021.103619. eCollection 2022 Jan 21.
The neuropeptide F (NPF) and its short version (sNPF) mediate food- and stress-related responses in solitary insects. In the honeybee, a social insect where food collection and defensive responses are socially regulated, only sNPF has an identified receptor. Here we increased artificially sNPF levels in honeybee foragers and studied the consequences of this manipulation in various forms of appetitive and aversive responsiveness. Increasing sNPF in partially fed bees turned them into the equivalent of starved animals, enhancing both their food consumption and responsiveness to appetitive gustatory and olfactory stimuli. Neural activity in the olfactory circuits of fed animals was reduced and could be rescued by sNPF treatment to the level of starved bees. In contrast, sNPF had no effect on responsiveness to nociceptive stimuli. Our results thus identify sNPF as a key modulator of hunger and food-related responses in bees, which are at the core of their foraging activities.
神经肽F（NPF）及其短版本（sNPF）介导独居昆虫中与食物和应激相关的反应。在蜜蜂这种社会性昆虫中，食物采集和防御反应是受社会调节的，只有sNPF有一个已确定的受体。在这里，我们人为提高了蜜蜂觅食者体内的sNPF水平，并研究了这种操作在各种形式的食欲和厌恶反应中的后果。在部分进食的蜜蜂中增加sNPF会使它们变成相当于饥饿动物的状态，增强它们的食物消耗以及对食欲性味觉和嗅觉刺激的反应。进食动物嗅觉回路中的神经活动减少，而sNPF处理可以将其恢复到饥饿蜜蜂的水平。相比之下，sNPF对伤害性刺激的反应没有影响。因此，我们的结果确定sNPF是蜜蜂饥饿和与食物相关反应的关键调节因子，而这些反应是它们觅食活动的核心。
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