Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Pharmacol Res Perspect. 2022 Feb;10(1):e00904. doi: 10.1002/prp2.904.
Diabetic cardiovascular complications and impaired cardiac function are considered to be the main causes of death in diabetic patients worldwide, especially patients with type 2 diabetes mellitus (T2DM). An increasing number of studies have shown that melatonin, as the main product secreted by the pineal gland, plays a vital role in the occurrence and development of diabetes. Melatonin improves myocardial cell metabolism, reduces vascular endothelial cell death, reverses microcirculation disorders, reduces myocardial fibrosis, reduces oxidative and endoplasmic reticulum stress, regulates cell autophagy and apoptosis, and improves mitochondrial function, all of which are the characteristics of diabetic cardiomyopathy (DCM). This review focuses on the role of melatonin in DCM. We also discuss new molecular findings that might facilitate a better understanding of the underlying mechanism. Finally, we propose potential new therapeutic strategies for patients with T2DM.
糖尿病心血管并发症和心脏功能障碍被认为是全球糖尿病患者，尤其是 2 型糖尿病（T2DM）患者死亡的主要原因。越来越多的研究表明，褪黑素作为松果腺分泌的主要产物，在糖尿病的发生发展中起着至关重要的作用。褪黑素可改善心肌细胞代谢，减少血管内皮细胞死亡，逆转微循环障碍，减少心肌纤维化，减轻氧化和内质网应激，调节细胞自噬和凋亡，改善线粒体功能，这些都是糖尿病心肌病（DCM）的特点。本综述重点讨论了褪黑素在 DCM 中的作用。我们还讨论了新的分子发现，这可能有助于更好地理解潜在的机制。最后，我们为 T2DM 患者提出了潜在的新治疗策略。
