Agnarsson B A, Kadin M E
Department of Pathology, Beth Israel Hospital, Boston, Massachusetts 02215.
Am J Clin Pathol. 1987 Dec;88(6):752-9. doi: 10.1093/ajcp/88.6.752.
The authors report an unusual B-cell lymphoma that simulated hairy cell leukemia (HCL) not only clinically but also pathologically in peripheral blood, bone marrow, and lymph node specimens. A diagnosis of lymphoma could be made only after pathologic examination of the spleen, indicating that caution should be exercised in making a primary diagnosis of HCL on bone marrow examination. Morphologically this lymphoma resembled monocytoid B-cell lymphoma (MBCL) but the immunophenotype (monoclonal Ig-kappa +, Ia+, B4+, Leu-1+, LN-2+, lambda-, Bl-, LN-1- and CALLA-) and clinical findings were more consistent with mantle zone lymphoma (MZL). Because this case demonstrates features of both MBCL and MZL, the authors suggest that these two entities may have a common histogenesis.
作者报告了一例不寻常的B细胞淋巴瘤，其不仅在临床症状上，而且在周围血、骨髓和淋巴结标本的病理表现上都酷似毛细胞白血病（HCL）。只有在对脾脏进行病理检查后才能做出淋巴瘤的诊断，这表明在通过骨髓检查对HCL做出初步诊断时应谨慎。形态学上，这种淋巴瘤类似于单核细胞样B细胞淋巴瘤（MBCL），但其免疫表型（单克隆Ig-κ +、Ia+、B4+、Leu-1+、LN-2+、λ-、Bl-、LN-1-和CALLA-）及临床发现更符合套细胞淋巴瘤（MZL）。由于该病例同时显示出MBCL和MZL的特征，作者认为这两种实体可能具有共同的组织发生学。
