Adami F, Chilosi M, Lestani M, Scarpa A, Zambello R, Pomponi F, Semenzato G, Menestrina F
Padua University School of Medicine, Department of Clinical Medicine, Italy.
Acta Haematol. 1993;89(2):94-9. doi: 10.1159/000204496.
A case of lymphoma presenting with features shared by hairy cell leukemia (HCL) and its variant, intermediate lymphocytic lymphoma (ILL) and monocytoid B-cell lymphoma (MBCL) is described. Clinical presentation and the morphological findings observed in peripheral blood and in bone marrow biopsy suggested an HCL; however, the tartrate-resistant acid phosphatase negativity of peripheral blood lymphocytes, the histologic pattern observed in the spleen, and the immunophenotyping of peripheral blood, spleen and bone marrow neoplastic lymphocytes (expression of CD5 and lack of CD25), were strongly against this hypothesis. The clinical course was aggressive. This report emphasizes the concept of the equivocal presentation of some 'low-grade' B-cell lymphomas. It is further pointed out that, even with complete and exhaustive morphological and immunological analyses, atypical cases may be encountered.
本文描述了一例淋巴瘤病例，其表现出毛细胞白血病（HCL）及其变异型、中间淋巴细胞淋巴瘤（ILL）和单核细胞样B细胞淋巴瘤（MBCL）的共同特征。临床表现以及外周血和骨髓活检中观察到的形态学结果提示为HCL；然而，外周血淋巴细胞的耐酒石酸酸性磷酸酶阴性、脾脏中观察到的组织学模式以及外周血、脾脏和骨髓肿瘤性淋巴细胞的免疫表型分析（CD5表达及CD25缺失），均强烈反对这一假设。临床病程呈侵袭性。本报告强调了一些“低度恶性”B细胞淋巴瘤表现不明确的概念。还进一步指出，即使进行了全面详尽的形态学和免疫学分析，仍可能遇到非典型病例。
