Department of Neurology, East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New Area, Shanghai, 200120, China.
Neurol Sci. 2022 Jun;43(6):3671-3675. doi: 10.1007/s10072-021-05830-x. Epub 2022 Jan 10.
To discover the associations between HMOX-1 and sporadic Parkinson's disease (PD).
Five hundred sporadic PD patients and 500 healthy controls were recruited in this study. Polymerase chain reaction (PCR) was used.
The dominant model of HMOX-1 rs2071747 was shown statistically significant between PD patients and control after adjustment of age and gender (dominant model: p value: 0.045, OR: 1.51, 95% CI: 1.01-2.27, adjusted). The associations of additive model and dominant model of rs2071747 were also found (additive model: p value: 0.047; dominant model: p value: 0.035, OR: 1.55, 95% CI: 1.03, 2.34).
We found the association of the dominant of HMOX1 rs2071747 with PD. We also found the associations of additive model and dominant model of HMOX1 rs2071747 with late onset PD (LOPD) patients.
• The dominant model of HMOX1 rs2071747 was associated with PD. • The additive model of HMOX1 rs2071747 was associated with LOPD. • The dominant model of HMOX1 rs2071747 was associated with LOPD.
发现 HMOX-1 与散发性帕金森病（PD）之间的关联。
本研究纳入了 500 例散发性 PD 患者和 500 名健康对照者。采用聚合酶链反应（PCR）法。
经年龄和性别调整后，PD 患者与对照组之间 HMOX-1 rs2071747 的显性模型存在统计学显著差异（显性模型：p 值：0.045，OR：1.51，95%CI：1.01-2.27）。rs2071747 的加性模型和显性模型也存在相关性（加性模型：p 值：0.047；显性模型：p 值：0.035，OR：1.55，95%CI：1.03，2.34）。
我们发现 HMOX1 rs2071747 的显性与 PD 相关。我们还发现 HMOX1 rs2071747 的加性模型和显性模型与晚发性 PD（LOPD）患者相关。
HMOX1 rs2071747 的显性模型与 PD 相关。
HMOX1 rs2071747 的加性模型与 LOPD 相关。
HMOX1 rs2071747 的显性模型与 LOPD 相关。
