Zhang Bei, Yu Hong-Xiang, Zhi Nan, Cui Can, Han Ying-Ying, Hu Min, Shen Hao, Bao Huan, Li Gang
Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Eur J Neurol. 2021 Sep;28(9):2922-2926. doi: 10.1111/ene.14870. Epub 2021 Jun 23.
The aim of this study was to discover the associations between HMOX-1 and Alzheimer's disease (AD).
A total of 500 AD patients and 500 healthy controls were recruited in this study. Polymer chain reaction was used.
There was a statistically significant difference between AD patients and controls in both the dominant and recessive models of HMOX-1 rs2071746 after adjustment for age, gender and education (dominant model: p = 0.047, odds ratio [OR] 1.34, 95% confidence interval [CI] 1.00-1.78, adjusted; recessive model: p = 0.049, OR 1.34, 95% CI 1.00-1.80, adjusted). There was also a trend for an association between the dominant model and late-onset AD after adjustment for age, gender and education (dominant model: p = 0.084, OR 1.37, 95% CI 0.96-1.95, adjusted).
We found an association between the dominant and recessive models of HMOX1 rs2071746 and AD.
本研究旨在发现血红素加氧酶-1（HMOX-1）与阿尔茨海默病（AD）之间的关联。
本研究共纳入500例AD患者和500例健康对照。采用聚合酶链反应。
在对年龄、性别和教育程度进行校正后，AD患者与对照组在HMOX-1 rs2071746的显性和隐性模型中均存在统计学显著差异（显性模型：p = 0.047，比值比[OR] 1.34，95%置信区间[CI] 1.00 - 1.78，校正后；隐性模型：p = 0.049，OR 1.34，95% CI 1.00 - 1.80，校正后）。在对年龄、性别和教育程度进行校正后，显性模型与晚发型AD之间也存在关联趋势（显性模型：p = 0.084，OR 1.37，95% CI 0.96 - 1.95，校正后）。
我们发现HMOX1 rs2071746的显性和隐性模型与AD之间存在关联。
