de Lange Mark J, Nell Rogier J, van der Velden Pieter A
Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
Mol Biomed. 2021 Aug 20;2(1):25. doi: 10.1186/s43556-021-00048-x.
Here, we discuss the presence and roles of heterogeneity in the development of uveal melanoma. Both genetic and cellular heterogeneity are considered, as their presence became undeniable due to single cell approaches that have recently been used in uveal melanoma analysis. However, the presence of precursor clones and immune infiltrate in uveal melanoma have been described as being part of the tumour already decades ago. Since uveal melanoma grow in the corpus vitreous, they present a unique tumour model because every cell present in the tumour tissue is actually part of the tumour and possibly plays a role. For an effective treatment of uveal melanoma metastasis, it should be clear whether precursor clones and normal cells play an active role in progression and metastasis. We propagate analysis of bulk tissue that allows analysis of tumour heterogeneity in a clinical setting.
在此，我们讨论葡萄膜黑色素瘤发展过程中异质性的存在及其作用。我们考虑了遗传异质性和细胞异质性，因为由于最近在葡萄膜黑色素瘤分析中使用的单细胞方法，它们的存在已不可否认。然而，几十年前就已将葡萄膜黑色素瘤中前体克隆和免疫浸润的存在描述为肿瘤的一部分。由于葡萄膜黑色素瘤生长于玻璃体中，它们呈现出一种独特的肿瘤模型，因为肿瘤组织中的每个细胞实际上都是肿瘤的一部分，并且可能发挥作用。为了有效治疗葡萄膜黑色素瘤转移，前体克隆和正常细胞在进展和转移中是否发挥积极作用应该明确。我们提倡对大块组织进行分析，这能够在临床环境中分析肿瘤异质性。
