State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
ACS Appl Bio Mater. 2021 Oct 18;4(10):7595-7604. doi: 10.1021/acsabm.1c00864. Epub 2021 Sep 15.
An injectable hydrogel sustained drug release system could be a promising technique for in situ treatment. Herein, an injectable hydrogel was prepared for photothermal-chemo therapy of cancer based on the thermosensitive liposomal hydrogel (Lip-Gel). The Lip-Gel system was fabricated by encapsulation of the NIR-II photothermal agent (DPP-BTz) and chemotherapy drugs (GEM) in thermosensitive liposomes and then combined with hydrogel precursor solution. The hydrogel precursor was used as an injectable flowing solution at room temperature and transferred into a cross-linked gel structure at physiological temperature. After being injected into the tumor, DPP-BTz in the Lip-Gel system can generate heat under irradiation of 1064 nm laser, breaking the thermosensitive liposomes and releasing GEM to kill tumor cells. From the treatment results, the Lip-Gel system showed a significant antitumor effect through chemo-/photothermal therapy combination therapy triggered by the NIR-II laser. This work provides a useful scheme for the development of drug delivery and drug treatment directions for local cancer therapy.
一种可注射水凝胶持续药物释放系统可能是原位治疗的一种有前途的技术。本文基于温敏脂质体水凝胶（Lip-Gel），制备了一种用于癌症光热化疗的可注射水凝胶。Lip-Gel 系统是通过将 NIR-II 光热剂（DPP-BTz）和化疗药物（GEM）封装在温敏脂质体中，并与水凝胶前体溶液结合而构建的。水凝胶前体在室温下用作可注射流动溶液，并在生理温度下转化为交联凝胶结构。注入肿瘤后，Lip-Gel 系统中的 DPP-BTz 在 1064nm 激光照射下产生热量，破坏温敏脂质体并释放 GEM 以杀死肿瘤细胞。从治疗结果来看，通过 NIR-II 激光触发的化疗/光热联合治疗，Lip-Gel 系统表现出显著的抗肿瘤效果。这项工作为局部癌症治疗的药物输送和药物治疗方向的发展提供了一个有用的方案。
