The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China.
Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
ACS Appl Bio Mater. 2021 May 17;4(5):3729-3738. doi: 10.1021/acsabm.0c00889. Epub 2020 Oct 27.
Because of the emergent evolution of multidrug-resistant (MDR) bacteria, resistance to traditional antibiotics has been increasingly causing public health concerns that it can rapidly overcome the development of antibacterial agents. Here, we demonstrated a facile electrodeposition method to prepare silver peroxysulfite (AgOHSO, AOHS) superpyramids on band-aids with extraordinary antibacterial performance. The porous structure and the sharp apex of AOHS superpyramids could facilitate the release of high-valence silver ions, which possess highly efficient MDR bacteria-killing effect and keep long-term antibacterial activity (>99% killing efficiency, recycle at least 4 times) because of their superior destruction capability of the membrane of the bacteria. A layer of copper was further evaporated onto the AOHS pyramids decorated on a band-aid, which could promote wound tissue angiogenesis and prohibit bacterial infection simultaneously, and finally accelerate the healing process in MDR bacteria-infected wound in vivo. The simple and low-cost fabrication process, as well as the outstanding antibacterial performance, make AOHS pyramids have promising applications in bacterial infection and practical sterilization fields, especially toward multidrug-resistant bacteria.
由于多药耐药（MDR）细菌的紧急进化，对传统抗生素的耐药性越来越引起公众健康的关注，因为它可能会迅速克服抗菌药物的发展。在这里，我们展示了一种简便的电沉积方法，可在创可贴上制备具有卓越抗菌性能的过氧硫酸银（AgOHSO，AOHS）超金字塔。AOHS 超金字塔的多孔结构和尖锐顶点可以促进高价银离子的释放，因为其具有高效的多药耐药菌杀伤作用，并保持长期的抗菌活性（>99%的杀伤效率，至少可循环使用 4 次），因为它们具有超强的破坏细菌膜的能力。进一步在创可贴上的 AOHS 金字塔上蒸镀一层铜，可同时促进伤口组织血管生成和抑制细菌感染，最终在体内多药耐药菌感染的伤口中加速愈合过程。简单且低成本的制造工艺以及出色的抗菌性能，使 AOHS 金字塔在细菌感染和实际灭菌领域具有广阔的应用前景，尤其是针对多药耐药菌。
