Liu Xinyu, Zhao Xing, Qiu Hongda, Liang Weida, Liu Linlin, Sun Yunyu, Zhao Lingling, Wang Xiao, Liang Hongze
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.
Anhui Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, School of Chemistry and Chemical Engineering, Suzhou University, Suzhou 234000, China.
Materials (Basel). 2025 Apr 21;18(8):1889. doi: 10.3390/ma18081889.
The development of antibiotic-independent antimicrobial materials is critical for addressing bacterial resistance to conventional antibiotics. Currently, there is a lack of comprehensive understanding of ionic liquid-modified composites in antimicrobial applications. Here, we innovatively prepared GO-based composites modified with phosphonate ionic liquids via a series of surface functionalizations. The resulting antibacterial composites exhibit significant broad-spectrum activity against both Gram-negative and Gram-positive bacteria, including drug-resistant strains, with stronger efficacy against Gram-negative species. Additionally, the material features excellent long-term reusability and the ability to inhibit/destroy biofilms, which is vital for combating persistent infections. Mechanistic studies reveal its antibacterial effects through multiple pathways: disrupting bacterial membranes, inducing ROS, and inactivating intracellular substances-mechanisms less likely to promote resistance. Overall, these phosphonate ionic liquid-modified polycationic materials demonstrate substantial potential in treating bacterial infections, offering a promising strategy to tackle antibiotic resistance challenges.
开发不依赖抗生素的抗菌材料对于应对细菌对传统抗生素的耐药性至关重要。目前，人们对离子液体改性复合材料在抗菌应用中的理解还不够全面。在此，我们通过一系列表面功能化创新地制备了用膦酸酯离子液体改性的基于氧化石墨烯的复合材料。所得抗菌复合材料对革兰氏阴性菌和革兰氏阳性菌均表现出显著的广谱活性，包括耐药菌株，对革兰氏阴性菌的效果更强。此外，该材料具有出色的长期可重复使用性以及抑制/破坏生物膜的能力，这对于对抗持续性感染至关重要。机理研究揭示了其通过多种途径的抗菌作用：破坏细菌膜、诱导活性氧以及使细胞内物质失活——这些机制不太可能促进耐药性。总体而言，这些膦酸酯离子液体改性的聚阳离子材料在治疗细菌感染方面显示出巨大潜力，为应对抗生素耐药性挑战提供了一种有前景的策略。
