Howard J, Sattler F, Mahon R, Sperling J, Leedom J
Edmund D. Edelman Health Center, Los Angeles, CA.
Arch Intern Med. 1987 Dec;147(12):2131-3.
We evaluated 100 human immunodeficiency virus (HIV) antibody-positive persons from the only alternate test site in Los Angeles. Thirty-five subjects complained of systemic symptoms suggestive of HIV infection and 65 were completely asymptomatic. Irrespective of symptoms, the group as a whole demonstrated clinical and laboratory evidence of immunodeficiency. Eighty had generalized lymphadenopathy, 16 onychomycosis, six oral candidiasis, and two biopsy-proved Kaposi's sarcoma. Seventy-seven were anergic to seven intradermal antigens. Despite normal white blood cell counts in most subjects, the T-helper-cell count was less than 300/mm3 in 48% of asymptomatic and 46% of symptomatic subjects. The degree of immune depression was less severe but approximated that of patients with acquired immunodeficiency syndrome after Pneumocystis carinii pneumonia. We believe these findings justify the need for comprehensive medical evaluation and follow-up care for seropositive persons from alternate test sites.
我们对来自洛杉矶唯一备用检测点的100名人类免疫缺陷病毒（HIV）抗体阳性者进行了评估。35名受试者主诉有提示HIV感染的全身症状，65名则完全无症状。无论有无症状，整个群体都表现出免疫缺陷的临床和实验室证据。80人有全身性淋巴结病，16人有甲癣，6人有口腔念珠菌病，2人经活检证实为卡波西肉瘤。77人对7种皮内抗原无反应。尽管大多数受试者白细胞计数正常，但在无症状受试者中，48%的人辅助性T细胞计数低于300/mm³，有症状受试者中这一比例为46%。免疫抑制程度较轻，但接近卡氏肺孢子虫肺炎后获得性免疫缺陷综合征患者的程度。我们认为，这些发现证明有必要对来自备用检测点的血清反应阳性者进行全面的医学评估和后续护理。
