College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center for Materials, Sichuan University, Chengdu 610065, China.
ACS Appl Bio Mater. 2021 Jun 21;4(6):5352-5361. doi: 10.1021/acsabm.1c00451. Epub 2021 May 13.
Tissue adhesives are widely desired in surgical wound closure and interfacial modification of medical devices. However, poor adhesive strength, low mechanical compliance, high costs, and biotoxicity of traditional adhesives limit their biomedical applications. In this work, we fabricated a class of mussel-inspired polyurethane adhesives (MPUAs) with robust properties, including in situ gel formation under mild conditions, accommodation of intricate wounds, strong adhesion, and good biocompatibility. Dopamine-modified lysine (LDA), as a chain extender, was incorporated into linear polyurethane as a crucial adhesive unit, and biologically sourced lysine was used as a mild curing agent for in situ gel. The premixed polyurethane adhesives can be fluently injected and can fill irregular and complicated defects. After mixing for several minutes, the adhesives can strongly bond multiple substrates, such as metallic materials, organic materials, and inorganic nonmetallic materials. In particular, they can strongly cohere the fresh (wet) biological tissues with a ductile interface, and the lap shear strength (24.5 ± 2.0 kPa) of the MPUAs was six times higher than that of the commercial fibrin glue. Moreover, the bursting pressure of MPUAs on the porcine aorta was 108.2 ± 3.8 mmHg, which can satisfy most of the surgical requirements (≤20 mmHg). Given its good biocompatibility, this system would provide potential applications in clinical surgery and biological coatings of medical devices.
在外科伤口闭合和医疗器械界面改性中，人们广泛希望使用组织粘合剂。然而，传统粘合剂的粘合强度差、机械顺应性低、成本高和生物毒性限制了它们在生物医学中的应用。在这项工作中，我们制备了一类具有良好性能的贻贝启发型聚氨酯粘合剂（MPUAs），包括在温和条件下原位形成凝胶、适应复杂伤口、具有较强的粘附性和良好的生物相容性。作为链扩展剂的多巴胺修饰赖氨酸（LDA）被掺入线性聚氨酯中，作为关键的粘合单元，并且生物来源的赖氨酸被用作原位凝胶的温和固化剂。预混合的聚氨酯粘合剂可以流畅地注入，并可以填充不规则和复杂的缺陷。混合几分钟后，粘合剂可以牢固地粘合多种基质，如金属材料、有机材料和无机非金属材料。特别是，它们可以牢固地粘结新鲜（湿）生物组织，并具有韧性界面，MPUAs 的搭接剪切强度（24.5±2.0 kPa）比商业纤维蛋白胶高 6 倍。此外，MPUAs 在猪主动脉上的爆破压力为 108.2±3.8mmHg，可以满足大多数手术要求（≤20mmHg）。鉴于其良好的生物相容性，该系统将为临床手术和医疗器械的生物涂层提供潜在的应用。
