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一种用于协同消毒耐抗生素病原体的稳定季铵化壳聚糖-黑磷纳米复合材料。

A Stable Quaternized Chitosan-Black Phosphorus Nanocomposite for Synergetic Disinfection of Antibiotic-Resistant Pathogens.

作者信息

Zhang Yi, Qu Xu-Fang, Zhu Cheng-Long, Yang Han-Jie, Lu Chen-Hui, Wang Wen-Long, Pang Yuehong, Yang Cheng, Chen Li-Jian, Li Xing-Fang

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi 214122, China.

出版信息

ACS Appl Bio Mater. 2021 Jun 21;4(6):4821-4832. doi: 10.1021/acsabm.1c00054. Epub 2021 May 16.

Abstract

Antibiotics are widely used for treatment of bacterial infections, and their overuse has contributed to microbial resistance. Currently, an alternative antibiotic-free therapy for inactivating bacteria is of great interest. Black phosphorus (BP), a biocompatible and nontoxic rising-star two-dimensional layered material, has gained remarkable interest in many bioapplications including biosensing, cancer therapy, drug delivery, and also antibacterial treatment. However, BP nanosheets suffer from instability in ambient environments due to rapid oxidation and degradation. To address this issue, BP nanosheets were modified with quaternized chitosan (QCS) by electrostatic adsorption to prepare a BP-QCS composite for photothermal/pharmaco treatment of bacterial infection. The BP-QCS has obviously enhanced solubility and chemical stability in aqueous suspensions. We have demonstrated that under near-infrared (NIR) irradiation, the BP-QCS can synergistically inactivate more than 95% methicillin-resistant (. ) (MRSA) and within 10 min with a dose of only 75 μg/mL in vitro. Meanwhile, the BP-QCS composite under NIR can synergistically inactivate 98% in vivo Furthermore, the BP-QCS suspensions at effective antibacterial concentrations have negligible cytotoxicity and in vivo toxicity.

摘要

抗生素被广泛用于治疗细菌感染,而其过度使用导致了微生物耐药性。目前,一种替代的无抗生素细菌灭活疗法备受关注。黑磷(BP)是一种具有生物相容性和无毒的新兴二维层状材料,在包括生物传感、癌症治疗、药物递送以及抗菌治疗在内的许多生物应用中引起了极大的兴趣。然而,由于快速氧化和降解,BP纳米片在环境中不稳定。为了解决这个问题,通过静电吸附用季铵化壳聚糖(QCS)对BP纳米片进行修饰,制备了用于细菌感染光热/药物治疗的BP-QCS复合材料。BP-QCS在水悬浮液中的溶解度和化学稳定性明显提高。我们已经证明,在近红外(NIR)照射下,BP-QCS在体外仅以75μg/mL的剂量在10分钟内可协同灭活超过95%的耐甲氧西林金黄色葡萄球菌(MRSA)。同时,NIR照射下的BP-QCS复合材料在体内可协同灭活98%的细菌。此外,有效抗菌浓度的BP-QCS悬浮液具有可忽略不计的细胞毒性和体内毒性。

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