Ullah Irfan, Khan Shahin Shah, Ahmad Waqar, Liu Luo, Rady Ahmed, Aldahmash Badr, Yu Changyuan, Wang Yushu
College of Life Science and Technology, Beijing University of Chemical Technology No. 15 East Road of North Third Ring Road, Chao Yang District Beijing 100029 China
Department of Zoology, College of Science, King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia.
RSC Adv. 2024 Jun 12;14(27):18871-18878. doi: 10.1039/d4ra01343c.
Bacteria invade the host's immune system, thereby inducing serious infections. Current treatments for bacterial infections mostly rely on single modalities, which cannot completely inhibit bacteria. This study evaluates the therapeutic potential of SeTe-Ag NPs, designed with excellent photo responsiveness, with a particular focus on their dual-action antibacterial effect and wound healing properties. SeTe-Ag NPs exhibited promising synergistic antibacterial effects due to their superior photothermal and photodynamic properties. The investigation records substantial zones of inhibition of bacteria, demonstrating potent antibacterial effect. Furthermore, upon the irradiation of near-infrared (NIR) light, SeTe-Ag NPs exhibit remarkable antibiofilm and wound-healing capabilities. Overall, this study shows the applications of NIR-active SeTe-Ag NPs, which serve as a versatile platform for biomedical applications.
细菌侵入宿主免疫系统，从而引发严重感染。目前针对细菌感染的治疗大多依赖单一方式，无法完全抑制细菌。本研究评估了具有出色光响应性的硒碲化银纳米颗粒（SeTe-Ag NPs）的治疗潜力，特别关注其双重抗菌作用和伤口愈合特性。由于具有卓越的光热和光动力特性，SeTe-Ag NPs展现出了有前景的协同抗菌效果。该研究记录了显著的抑菌圈，证明其具有强大的抗菌作用。此外，在近红外（NIR）光照射下，SeTe-Ag NPs表现出显著的抗生物膜和伤口愈合能力。总体而言，本研究展示了近红外活性SeTe-Ag NPs的应用，其可作为生物医学应用的多功能平台。
