Han Hecheng, Xu Xiaoying, Kan Haopeng, Tang Yunxiang, Liu Chang, Wen Hongling, Wu Lili, Jiang Yanyan, Wang Zhou, Liu Jiurong, Wang Fenglong
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of Education, Shandong University, Jinan 250061, China.
Department of Virology, School of Public Health, Shandong University, Jinan, Shandong 250012, China.
J Colloid Interface Sci. 2022 Jun 15;616:304-315. doi: 10.1016/j.jcis.2022.02.068. Epub 2022 Feb 18.
Globally, drug-resistant bacteria are a potential threat to human society owing to the overuse of antibiotics and thus, non-antibiotic bactericides are urgently needed. Herein, an innovative antibacterial nanoplatform based on quaternized chitosan (QCS)/ silver (Ag)/ cobalt phosphide (CoP) nanocomposites is envisaged for achieving near-infrared (NIR) laser-inducible rapid sterilisation. In the core-shell hybrids, Ag nanoparticles (NPs) with a size of ∼ 25 nm were uniformly deposited on CoP nanoneedles, upon which a layer of QCS (approximately 10 wt%), is coated. Numerical calculations revealed that under NIR irradiation, high-energy hot electrons arising from the surface plasmon resonance effect of Ag migrate into the interface between Ag and CoP, and amplify the photothermal effect of CoP. Meanwhile, photo-excited electrons from CoP are transported onto Ag NPs because the Schottky heterostructure facilitates the production of reactive oxygen species. Ag loading simultaneously enhances the photocatalytic and photothermal effects of CoP, achieving rapid antibacterial activity synergistically. The QCS coating improves the dispersibility of power in an aqueous system and provides contact between the antiseptics and bacteria. The ternary QCS/Ag/CoP nanocomposites achieved greater than 99.6% inactivation against S. aureus and E. coli within 10 min. In addition, the nanocomposites were confirmed to be noncytotoxic to mammals. Consequently, the QCS/Ag/CoP nanoplatforms possess great potential for rapid and effective antibacterial applications.
在全球范围内，由于抗生素的过度使用，耐药细菌对人类社会构成了潜在威胁，因此，迫切需要非抗生素杀菌剂。在此，设想了一种基于季铵化壳聚糖（QCS）/银（Ag）/磷化钴（CoP）纳米复合材料的创新抗菌纳米平台，以实现近红外（NIR）激光诱导的快速杀菌。在核壳杂化物中，尺寸约为25 nm的Ag纳米颗粒（NPs）均匀沉积在CoP纳米针上，其上涂覆有一层QCS（约10 wt%）。数值计算表明，在近红外辐射下，由Ag的表面等离子体共振效应产生的高能热电子迁移到Ag和CoP之间的界面，并放大CoP的光热效应。同时，由于肖特基异质结构促进了活性氧的产生，来自CoP的光激发电子被传输到Ag NPs上。Ag负载同时增强了CoP的光催化和光热效应，协同实现了快速抗菌活性。QCS涂层提高了粉末在水体系中的分散性，并提供了防腐剂与细菌之间的接触。三元QCS/Ag/CoP纳米复合材料在10分钟内对金黄色葡萄球菌和大肠杆菌的灭活率大于99.6%。此外，该纳米复合材料被证实对哺乳动物无细胞毒性。因此，QCS/Ag/CoP纳米平台在快速有效的抗菌应用方面具有巨大潜力。
