Song Jintong, Xie Fei, Luan Xiaoyi, Xu Ke, Qian Lilin, Lu Jinghui, Chang Wenqiang, Wang Xiaoning, Lou Hongxiang
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, P.R. China.
Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, P.R. China.
Nat Prod Res. 2023 May;37(9):1527-1535. doi: 10.1080/14786419.2021.2025366. Epub 2022 Jan 10.
Five undescribed perylenequinone derivatives (PQDs) phialocephalarins H - L (-), together with two known PQDs phialocephalarins A - B (, ) and one known spirobisnaphthalene palmarumycin P3 () were isolated from the endolichenic fungus Their structures were elucidated on the basis of NMR and HRESIMS data as well as electronic circular dichroism (ECD) calculations. Compounds , , , and - were evaluated for cytotoxic activities against NCI-H460, NCI-H446, PC3, and EC109 cell lines. The results showed that compounds , , , and showed cytotoxic activities against EC109 cells with IC values ranging from 24.5 to 33.3 M.
从内生地衣真菌中分离出五个未描述的苝醌衍生物（PQDs）——phialocephalarins H - L（-），以及两个已知的PQDs——phialocephalarins A - B（，）和一个已知的螺双萘骈棕榈霉素P3（）。基于核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）数据以及电子圆二色光谱（ECD）计算对它们的结构进行了阐明。对化合物、、、和 - 针对NCI-H460、NCI-H446、PC3和EC109细胞系的细胞毒性活性进行了评估。结果表明，化合物、、、和 对EC109细胞表现出细胞毒性活性，IC值范围为24.5至33.3 μM。
