细胞毒性七环倍半萜类化合物来自内生菌真菌。
Cytotoxic Heptaketides from the Endolichenic Fungus .
机构信息
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
Department of Pharmacy, Qilu Hospital of Shandong University, Jinan250012, People's Republic of China.
出版信息
J Nat Prod. 2020 May 22;83(5):1623-1633. doi: 10.1021/acs.jnatprod.0c00108. Epub 2020 May 12.
Eleven new metabolites including nine heptaketides, ulosporin A-G (-), one diphenyl compound, ulophenol (), and one spirobisnaphthalene, palmarumycin P5 (), were isolated from the endolichenic fungus , which inhabits the lichen sp. The structures of these compounds were elucidated based on comprehensive analysis of their spectroscopic, electronic circular dichroism (ECD), and single-crystal X-ray diffraction data. Ulosporin G () inhibited the growth of the human cancer cell lines A549, MCF-7, and KB with IC values of 1.3, 1.3, and 3.0 μM, respectively. Additionally, it induced A549 cell apoptosis through G0/G1 cell cycle arrest caused by DNA damage.
从内生真菌中分离得到 11 种新代谢产物，包括 9 种庚烷酮，1 种二苯化合物，ulopenol A-G(-)，1 种二苯化合物，ulopenol( )和 1 种螺双萘并[2,1-b:1',2'-e]呋喃 palmarumycin P5()。这些化合物的结构是基于它们的光谱、电子圆二色性（ECD）和单晶 X 射线衍射数据的综合分析来阐明的。Uosporin G()对人癌细胞系 A549、MCF-7 和 KB 的生长具有抑制作用，IC 值分别为 1.3、1.3 和 3.0 μM。此外，它通过 DNA 损伤引起的 G0/G1 细胞周期阻滞诱导 A549 细胞凋亡。
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