Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, The Islamic University, Najaf, Iraq.
Nat Prod Res. 2022 Nov;36(22):5747-5752. doi: 10.1080/14786419.2021.2023868. Epub 2022 Jan 10.
A new phytoconstituent; (6Z,9Z)-heptadeca-6,9-diene-5,11-dione () was isolated from methanol extract. The structure of was determined based on the analysis of NMR spectra and HRESIMS. It was tested for antimicrobial and antiprotozoal activities. Compound showed leishmanicidal activity against amastigote with an IC of 16.4394 µM and IC of 28.9015 µM and a weak antitrypanosomal activity with an IC of 37.6136 µM. The cytotoxicity of was evaluated using standard experimental procedures against THP1 cells and no cytotoxicity was observed indicating its selectivity and safety.Supplemental data for this article can be accessed here.
从甲醇提取物中分离得到一个新的植物成分；（6Z，9Z）-十七碳-6,9-二烯-5,11-二酮（）。基于 NMR 谱和 HRESIMS 的分析，确定了的结构。对其进行了抗菌和抗原生动物活性测试。化合物对 前鞭毛体表现出杀利什曼原虫活性，IC 为 16.4394 μM 和 IC 为 28.9015 μM，对锥虫具有较弱的抗活性，IC 为 37.6136 μM。采用标准实验程序对 THP1 细胞进行了 的细胞毒性评估，未观察到细胞毒性，表明其选择性和安全性。本文的补充数据可在此处获取。
