J Neurosci Nurs. 2022 Feb 1;54(1):30-34. doi: 10.1097/JNN.0000000000000635.
The Bispectral (BIS) monitor is a validated, noninvasive monitor placed over the forehead to titrate sedation in patients under general anesthesia in the operating room. In the neurocritical care unit, there is limited room on the forehead because of incisions, injuries, and other monitoring devices. This is a pilot study to determine whether a BIS nasal montage correlates to the standard frontal-temporal data in this patient population. METHODS: This prospective nonandomized pilot study enrolled 10 critically ill, intubated, and sedated adult patients admitted to the neurocritical care unit. Each patient had a BIS monitor placed over the standard frontal-temporal location and over the alternative nasal dorsum with simultaneous data collected for 24 hours. RESULTS: In the frontal-temporal location, the mean (SD) BIS score was 50.9 (15.0), average minimum BIS score was 47.0 (15.0), and average maximum BIS score was 58.4 (16.7). In the nasal dorsum location, the mean BIS score was 54.8 (21.6), average minimum BIS score was 52.8 (20.9), and average maximum BIS score was 58.0 (22.2). Baseline nonparametric tests showed nonsignificant P values for all variables except for Signal Quality Index. Generalized linear model analysis demonstrated significant differences between the 2 monitor locations (P < .0001). CONCLUSION: The results of this pilot study do not support using a BIS nasal montage as an alternative for patients in the neurocritical care unit.
双频谱指数（BIS）监测仪是一种经过验证的非侵入性监测仪，放置在前额上方，用于在手术室全身麻醉下滴定镇静。在神经重症监护病房，由于切口、损伤和其他监测设备，前额的空间有限。这是一项初步研究，旨在确定 BIS 鼻导联与该患者群体的标准额颞数据是否相关。方法：这项前瞻性非随机初步研究纳入了 10 名重症、插管和镇静的成年患者，这些患者被收入神经重症监护病房。每位患者均在前额标准位置和替代的鼻背位置放置 BIS 监测仪，并同时收集 24 小时的数据。结果：在前额位置，BIS 评分的平均值（标准差）为 50.9（15.0），平均最小 BIS 评分为 47.0（15.0），平均最大 BIS 评分为 58.4（16.7）。在鼻背位置，BIS 评分的平均值为 54.8（21.6），平均最小 BIS 评分为 52.8（20.9），平均最大 BIS 评分为 58.0（22.2）。基线非参数检验显示，除信号质量指数外，所有变量的 P 值均无统计学意义。广义线性模型分析显示，两个监测位置之间存在显著差异（P<.0001）。结论：这项初步研究的结果不支持在神经重症监护病房中使用 BIS 鼻导联作为替代方法。
