Long Noncoding RNA Suppresses Cell Proliferation, Migration, and Invasion of Bladder Cancer via / Axis.

Bladder cancer (BC) is the most common type of malignant tumor in the genitourinary system. Through the microarray analysis of clinical samples, long noncoding RNA expression was found to be downregulated in BC tissues. However, the function of on BC and underlying mechanism are unclear. In this study, the correlations of with clinicopathological parameters in BC patients were determined. The gain- and loss-of-function experiments were conducted to examine the role of in malignant behaviors of BC cells and . Then, we paid attention to / axis to illustrate the molecular mechanism. Results showed that was downregulated in BC tissues, and its overexpression significantly inhibited cell proliferation, migration, and invasion , as well as tumor growth . Knockdown of caused an opposite effect on BC cell malignancies. Furthermore, was shown to be a direct target of , and it reversed the inhibitory effect of on BC malignancies. Also, as a downstream factor of , silencing was demonstrated to mediate the role of inhibitor in BC cell proliferation and invasion. Thus, it suggests that acts as a suppressor in BC development through / axis.