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HAND2-AS1 通过作为 miR-3118 的 ceRNA 来上调 PHLPP2 抑制乳腺癌的增殖和迁移。

HAND2-AS1 Works as a ceRNA of miR-3118 to Suppress Proliferation and Migration in Breast Cancer by Upregulating PHLPP2.

机构信息

Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

The 3rd Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

出版信息

Biomed Res Int. 2020 Sep 14;2020:8124570. doi: 10.1155/2020/8124570. eCollection 2020.

DOI:10.1155/2020/8124570
PMID:33015182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7512048/
Abstract

Large quantities of long noncoding RNAs (lncRNAs) have been verified to exert vital functions in the process of breast cancer (BC). lncRNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1) was reported to suppress the development of several cancers. However, its detailed function in BC remained unclear. In the current study, HAND2-AS1 was discovered to be low expressed in BC cell lines, and overexpression of HAND2-AS1 could repress proliferation, migration, and invasion but facilitate apoptosis in BC cells. Moreover, HAND2-AS1 was found to act as a sponge of miR-3118 which was detected to be upregulated in BC cell lines. miR-3118 depletion could constrict the progression of BC. HAND-AS1 hindered the course of BC by reducing the expression of miR-3118. Besides, PHLPP2 was treated as a downstream target of miR-3118 under the selection of RNA pull-down assays. HAND2-AS1 inhibited the process of BC by enhancing expression of PHLPP2. In summary, our study testified that HAND2-AS1 suppressed BC growth by targeting the miR-3118/PHLPP2 axis, indicating that HAND2-AS1 could be regarded as a potential target for BC treatment.

摘要

大量长链非编码 RNA（lncRNA）已被证实在乳腺癌（BC）过程中发挥重要作用。lncRNA 心和神经嵴衍生物表达 2-反义 RNA 1（HAND2-AS1）被报道抑制几种癌症的发展。然而，其在 BC 中的详细功能仍不清楚。在本研究中，发现 HAND2-AS1 在 BC 细胞系中低表达，过表达 HAND2-AS1 可抑制 BC 细胞的增殖、迁移和侵袭，但促进凋亡。此外，发现 HAND2-AS1 可作为 miR-3118 的海绵，miR-3118 在 BC 细胞系中上调。miR-3118 耗竭可抑制 BC 的进展。HAND-AS1 通过降低 miR-3118 的表达来阻碍 BC 的发生。此外，通过 RNA 下拉测定筛选出 PHLPP2 作为 miR-3118 的下游靶标。HAND2-AS1 通过增强 PHLPP2 的表达抑制 BC 的发生。总之，我们的研究证实 HAND2-AS1 通过靶向 miR-3118/PHLPP2 轴抑制 BC 生长，表明 HAND2-AS1 可作为 BC 治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/1229e936143b/BMRI2020-8124570.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/683d1f819b41/BMRI2020-8124570.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/d01efb1f5473/BMRI2020-8124570.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/b12a90abdaa9/BMRI2020-8124570.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/ff6283b235ef/BMRI2020-8124570.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/56aa1dd6cb85/BMRI2020-8124570.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/1229e936143b/BMRI2020-8124570.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/683d1f819b41/BMRI2020-8124570.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/d01efb1f5473/BMRI2020-8124570.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/b12a90abdaa9/BMRI2020-8124570.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/ff6283b235ef/BMRI2020-8124570.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/56aa1dd6cb85/BMRI2020-8124570.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f970/7512048/1229e936143b/BMRI2020-8124570.006.jpg

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