Abdel-Rahman R M, Vishakha V, Kelnar I, Jancar J, Abdel-Mohsen A M
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, Praha 162 06, Czech Republic.
CEITEC-Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, Brno 61200, Czech Republic.
Int J Biol Macromol. 2022 Mar 31;202:671-680. doi: 10.1016/j.ijbiomac.2022.01.004. Epub 2022 Jan 8.
Hybrid biocomposite scaffolds (HBS) that serve as a carrier for cell proliferation and differentiation are increasingly used for tissue regeneration. 3D hybrid scaffold based on collagen-grafted-chitosan-glucan fiber (CO-g-CGF-HBS) was prepared by freeze-drying technique. The swelling percentage, hydrolytic stability, and modulus of elasticity of HBS were enhanced after the chemical modification of CO with CGF. Pore size and porosity of HBS were decreased with an increased CGF ratio. HBS exhibits a higher reduction rate against different types of bacteria compared with a control sample. Thus, chemical modification of CO with different ratios of CGF significantly improved the physicochemical, antibacterial properties of HBS.
作为细胞增殖和分化载体的混合生物复合支架（HBS）越来越多地用于组织再生。通过冷冻干燥技术制备了基于胶原接枝壳聚糖-葡聚糖纤维的三维混合支架（CO-g-CGF-HBS）。用CGF对CO进行化学改性后，HBS的溶胀率、水解稳定性和弹性模量得到提高。随着CGF比例的增加，HBS的孔径和孔隙率降低。与对照样品相比，HBS对不同类型细菌的还原率更高。因此，用不同比例的CGF对CO进行化学改性显著改善了HBS的物理化学和抗菌性能。
