MSL-In Laboratory, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium; Psychiatric Hospital Area+/Epsylon, ASBL, Brussels, Belgium.
Psychiatric Hospital Area+/Epsylon, ASBL, Brussels, Belgium.
J Affect Disord. 2022 Mar 15;301:145-153. doi: 10.1016/j.jad.2022.01.011. Epub 2022 Jan 7.
Physical exercise therapy is of proven efficacy in the treatment of adults with depression, but corresponding evidence is lacking in depressed adolescent inpatients. The aim of this study was to document the effect of add-on treatment with structured physical exercise in a clinical population of adolescents hospitalized for depression and anxiety in a psychiatric hospital.
A group of 52 adolescent inpatients was randomly assigned to a physical exercise or control program three to four times per week over a six-week period (20 hours in total). The primary outcome was the Hospital Anxiety Depression Scale (HADS) for evaluation of depression and anxiety symptoms. Secondary outcomes were psychological self-assessments, diagnostic interviews, and physical examinations.
Six participants were lost in each group, leaving 20 inpatients each in the intervention and control groups. A linear mixed model with F-test revealed a significant interaction in favor of physical exercise in reducing the mean depression score (HADS-D) by 3.8 points [95% (CI), range 1.8 to 5.7], compared to a mean reduction score of 0.7 [95% (CI), range -0,7 to 2.0] in the control group. No significant interaction was found for anxiety symptoms (HADS-A).
The investigation was limited to the six-week hospital window and the small sample size prevented exploring differences in social characteristics.
Structured physical exercise add-on therapy integrated into the psychiatric hospitalization of adolescents has led to a reduction in their depressive symptoms, demonstrating its effectiveness in the care of adolescent inpatients with depression.
运动疗法已被证实对治疗成人抑郁症有效，但针对住院抑郁青少年的相应证据尚缺乏。本研究旨在记录在精神病院住院的抑郁和焦虑青少年患者中，附加结构性运动治疗的效果。
将 52 名青少年住院患者随机分配到运动或对照组，每周进行 3-4 次、共 6 周（总计 20 小时）的治疗。主要结局是使用医院焦虑抑郁量表（HADS）评估抑郁和焦虑症状。次要结局是心理自评、诊断访谈和体格检查。
每组各有 6 名参与者失访，干预组和对照组各有 20 名住院患者。线性混合模型 F 检验显示，与对照组（平均降低 0.7 分[95%（CI）范围-0.7 至 2.0]）相比，运动组的 HADS-D 平均降低 3.8 分（95%（CI）范围 1.8 至 5.7）具有显著的交互作用，有利于运动。对焦虑症状（HADS-A）无显著交互作用。
该研究仅限于 6 周的住院时间窗口，且样本量小，无法探索社会特征的差异。
将结构性运动附加治疗纳入青少年精神病住院治疗中，可降低其抑郁症状，表明其对住院抑郁青少年患者的护理有效。
