Department of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105, BA, Amsterdam, the Netherlands.
Department of Psychological Methods, University of Amsterdam, Valckeniersstraat 59, 1018, XA, Amsterdam, the Netherlands.
J Psychiatr Res. 2022 Mar;147:34-38. doi: 10.1016/j.jpsychires.2022.01.008. Epub 2022 Jan 5.
To validate a faster speed of response to electroconvulsive therapy (ECT) for bipolar depression (BPD) compared to major depressive disorder (MDD) METHOD: Retrospective chart review on an ECT cohort in an academic hospital setting. Speed of response was defined by the number of ECT treatments needed for response or remission.
Sixty-four depressed patients were included, of whom 53 (MDD: 40, BPD: 13) could be analyzed. The bipolar group responded faster with a mean difference of 3.3 fewer ECT treatments to meet response criteria (MDD 10.4 vs. BPD 7.1, p = 0.054). When using mixed effects regression models for the response/remitter group (n = 35), a faster response for the bipolar group (AIC 252.83 vs 258.55, χ = 11.72, p = 0.008) was shown. Other factors, such as psychotic features or comorbidity, did not influence the speed of response.
This chart review of an ECT cohort in an naturalistic academic hospital setting shows an evident and clinically relevant faster speed of response in bipolar depression.
验证与重度抑郁症（MDD）相比，双相情感障碍（BPD）患者对电抽搐治疗（ECT）的反应速度更快。
对学术医院环境中的 ECT 队列进行回顾性图表审查。反应速度定义为达到反应或缓解所需的 ECT 治疗次数。
共纳入 64 名抑郁患者，其中 53 名（MDD：40 名，BPD：13 名）可进行分析。双相组的反应速度更快，达到反应标准所需的 ECT 治疗次数平均减少 3.3 次（MDD：10.4 次，BPD：7.1 次，p=0.054）。当对反应/缓解组（n=35）使用混合效应回归模型时，显示出双相组的反应更快（AIC 252.83 与 258.55，χ=11.72，p=0.008）。其他因素，如精神病特征或合并症，并不影响反应速度。
本研究对自然学术医院环境中的 ECT 队列进行了图表审查，结果显示在双相情感障碍中，电抽搐治疗的反应速度明显更快，且具有临床相关性。
