Barbera C, Fusco P, Ansaldi N, DeMarchi M, Carbonara A
Servizio di Gastroenterologia, Università di Siena, Italy.
Diagn Clin Immunol. 1987;5(3):158-61.
IgG and IgA antigluten antibodies (Gab) were assayed in 83 celiac disease (CD) patients typed for HLA and Gm markers. Their titer and frequency were lower when a gluten-free diet was given than in active CD; these were significantly correlated, whereas no correlation was found between titer and serum Ig. Persistence of high titers was mainly confined to HLA-DR3 negative females (45% vs 6.7% of DR3 positive females and 19.3% of males). No association was found with any Gm allotype, in contrast with the previously reported involvement of the "fnb" haplotype with both CD susceptibility and Gab persistence in patients on a gluten-free diet. A technical and/or genetic explanation could be given for these differences.
对83名进行了HLA和Gm标记分型的乳糜泻（CD）患者检测了IgG和IgA抗麸质抗体（Gab）。给予无麸质饮食时，其滴度和频率低于活动期CD患者；这些指标显著相关，而滴度与血清Ig之间未发现相关性。高滴度的持续存在主要局限于HLA-DR3阴性女性（DR3阳性女性为6.7%，男性为19.3%，与之相比为45%）。未发现与任何Gm同种异型相关，这与之前报道的“fnb”单倍型在无麸质饮食患者中与CD易感性和Gab持续存在均有关联形成对比。可以对这些差异给出技术和/或遗传学解释。
