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Urinary exosomal circular RNAs of sex chromosome origin are associated with gender-related risk differences of clinicopathological features in patients with IgA nephropathy.性染色体来源的尿液外泌体环状RNA与IgA肾病患者临床病理特征的性别相关风险差异有关。
J Nephrol. 2022 May;35(4):1069-1078. doi: 10.1007/s40620-021-01118-7. Epub 2021 Jul 22.
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Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea.与磺脲类药物相比，服用二肽基肽酶-4抑制剂的2型糖尿病患者尿外泌体微小RNA谱分析
Kidney Res Clin Pract. 2021 Sep;40(3):383-391. doi: 10.23876/j.krcp.21.015. Epub 2021 Jul 7.
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Effect of diabetes on exosomal miRNA profile in patients with obesity.糖尿病对肥胖患者外泌体微小RNA谱的影响。
BMJ Open Diabetes Res Care. 2020 Sep;8(1). doi: 10.1136/bmjdrc-2020-001403.
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Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes.饮食与胃旁路手术对糖尿病代谢功能的影响。
N Engl J Med. 2020 Aug 20;383(8):721-732. doi: 10.1056/NEJMoa2003697.
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A novel, pathogenic dinucleotide deletion in the mitochondrial MT-TY gene causing myasthenia-like features.一个新的致病性线粒体 MT-TY 基因中的二核苷酸缺失导致类重症肌无力特征。
Neuromuscul Disord. 2020 Aug;30(8):661-668. doi: 10.1016/j.nmd.2020.06.008. Epub 2020 Jun 24.
6
The profiles of microRNAs from urinary extracellular vesicles (EVs) prepared by various isolation methods and their correlation with serum EV microRNAs.不同分离方法得到的尿细胞外囊泡（EV）中的 microRNAs 特征及其与血清 EV microRNAs 的相关性。
Diabetes Res Clin Pract. 2020 Feb;160:108010. doi: 10.1016/j.diabres.2020.108010. Epub 2020 Jan 24.
7
Obesity associated with a novel mitochondrial tRNACys 5802A>G mutation in a Chinese family.中国人中一个新的线粒体 tRNACys 5802A>G 突变与肥胖相关。
Biosci Rep. 2020 Jan 31;40(1). doi: 10.1042/BSR20192153.
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Differential Expression of Urinary Exosomal MicroRNAs miR-21-5p and miR-30b-5p in Individuals with Diabetic Kidney Disease.尿外泌体 microRNAs miR-21-5p 和 miR-30b-5p 在糖尿病肾病患者中的差异表达。
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体重变化改变肥胖状态下尿液细胞外囊泡的小RNA谱。

Weight Change Alters the Small RNA Profile of Urinary Extracellular Vesicles in Obesity.

作者信息

Choi Dughyun, Kim Sewon, Woo Jeyoung, Lee Haekyung, Kim Hyoungnae, Jeon Jin Seok, Noh Hyunjin, Han Dong Cheol, Kim Sang Hyun, Cho Ho Chan, Choi Jong-Soo, Bae Yun-Ui, Kwon Soon Hyo

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Macrogen Inc., Seoul, Republic of Korea.

出版信息

Obes Facts. 2022;15(2):292-301. doi: 10.1159/000521730. Epub 2022 Jan 10.

DOI:10.1159/000521730
PMID:35008090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9021654/
Abstract

INTRODUCTION

Various kidney diseases reportedly show different urinary extracellular vesicle (EV) RNA profiles. Although obesity is one of the main causes of chronic kidney disease, the expression pattern of urinary EV RNA in obesity is uncertain. Our aim was to sequence the small RNA profiles of urinary EVs in obese patients before and after weight reduction and compare them to those of healthy volunteers (HVs).

METHODS

We recruited age-sex-matched obese patients and HVs. The small RNA profiles of urinary EVs were analyzed using RNA sequencing. To evaluate the effect of weight reduction, small RNA profiles of urinary EVs 6 months after bariatric surgery were also analyzed.

RESULTS

The proportion of urinary EVs transfer RNA and microRNA of obese patients differed from that of HVs. Obese patients showed differential expression of 1,343 small RNAs in urinary EVs compared to HVs (fold change ≥2 and p value <0.05). Among those, 61 small RNAs were upregulated in obese patients and downregulated after weight reduction, whereas 167 small RNAs were downregulated in obese patients and upregulated after weight reduction. RNA sequencing revealed the correlation between the specific urinary EV small RNAs and clinical parameters including body weight, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol, serum glucose, estimated glomerular filtration rate, and albuminuria.

CONCLUSION

Obese patients showed distinct urinary EV small RNA profiles compared to HVs. Weight reduction altered urinary EV small-RNA profiles in obese patients.

摘要

引言

据报道，各种肾脏疾病表现出不同的尿细胞外囊泡（EV）RNA谱。尽管肥胖是慢性肾脏病的主要病因之一，但肥胖患者尿EV RNA的表达模式尚不确定。我们的目的是对肥胖患者减重前后尿EV的小RNA谱进行测序，并将其与健康志愿者（HV）的进行比较。

方法

我们招募了年龄和性别匹配的肥胖患者和HV。使用RNA测序分析尿EV的小RNA谱。为了评估减重的效果，还分析了减肥手术后6个月尿EV的小RNA谱。

结果

肥胖患者尿EV转运RNA和微小RNA的比例与HV不同。与HV相比，肥胖患者尿EV中有1343种小RNA表达存在差异（倍数变化≥2且p值<0.05）。其中，61种小RNA在肥胖患者中上调，减重后下调，而167种小RNA在肥胖患者中下调，减重后上调。RNA测序揭示了特定尿EV小RNA与包括体重、低密度脂蛋白胆固醇、甘油三酯、高密度脂蛋白胆固醇、血糖、估计肾小球滤过率和蛋白尿在内的临床参数之间的相关性。

结论

与HV相比，肥胖患者表现出独特的尿EV小RNA谱。减重改变了肥胖患者尿EV的小RNA谱。