Fan J L, Himeno K, Tsuru S, Nomoto K
Department of Immunology, Kyushu University, Fukuoka, Japan.
Clin Exp Immunol. 1987 Oct;70(1):94-101.
The autoimmune manifestations of MRL/Mp-lpr/lpr(MRL/l), a murine model of systemic lupus erythematosus (SLE), were alleviated by administering 1 microgram cholera toxin (CT) every 14 days. The beneficial effects were: (i) significant prolongation of survival time, (ii) prevention of lymphadenopathy, (iii) improvement of T cell mitogenic responses and suppression of a B cell mitogenic response, (iv) decrease in serum anti-DNA and anti-Sm antibodies, (v) increase in IL-2 production by stimulation of spleen cells with concanavalin A (Con A). It is possible that CT may be effective for treatment of murine lupus nephritis by modulating polyclonal lymphocyte activation. This type of immunomodulation may pave the way toward treatment of lupus and other autoimmune diseases.
通过每14天给予1微克霍乱毒素（CT），系统性红斑狼疮（SLE）小鼠模型MRL/Mp-lpr/lpr（MRL/l）的自身免疫表现得到缓解。其有益效果包括：（i）显著延长存活时间；（ii）预防淋巴结病；（iii）改善T细胞促有丝分裂反应并抑制B细胞促有丝分裂反应；（iv）血清抗DNA和抗Sm抗体减少；（v）通过用伴刀豆球蛋白A（Con A）刺激脾细胞增加白细胞介素-2的产生。CT有可能通过调节多克隆淋巴细胞活化来有效治疗小鼠狼疮性肾炎。这种免疫调节类型可能为狼疮和其他自身免疫性疾病的治疗铺平道路。
